{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:30:50Z","timestamp":1775115050315,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aim to investigate the relationship between bone mass in a sample of Brazilian individuals with DS and handgrip strength, body mass index (BMI) and physical exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dual\u2010energy X\u2010ray emission densitometry analysis of bone mass in 26 individuals with DS (8 men and 18 women with a mean age of 30.7\u00a0\u00b1\u00a010.3\u00a0years) was conducted. Additionally, weight and height were measured to determine BMI, palmar grip strength was measured using a Jammar dynamometer\u00ae, and physical activity was classified using the International Physical Activity Questionnaire (IPAQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this sample, 2\/15 (13.3%) individuals with age between 18 to 29\u00a0years had low BMD in the spine; 2\/8 (25%) of those with age between 30 and 39\u00a0years also had low BMD in the spine and 2\/3 (66.6%) with age \u226540 had low BMD in the femur. There were significant correlations between palmar grip strength and Z femoral neck score in women (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and between BMI and Z femoral neck score in men (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). All other correlations lacked statistical significance (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brazilian patients with DS showed a high prevalence of low bone mass. Traditional factors such as muscle strength, BMI and physical activity appear to have little effect on bone mineral density in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13031","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T08:19:39Z","timestamp":1681719579000},"page":"796-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bone mineral density in adults with Down syndrome: a cross\u2010sectional study in a Brazilian sample"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-1089","authenticated-orcid":false,"given":"A.","family":"Fedrigo","sequence":"first","affiliation":[{"name":"Internal Medicine Post Graduate, Clinical Hospital Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-3542","authenticated-orcid":false,"given":"T. L.","family":"Skare","sequence":"additional","affiliation":[{"name":"Department of Medicine Mackenzie Evangelical School of Medicine Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3840-7485","authenticated-orcid":false,"given":"G. R.","family":"Levandoski","sequence":"additional","affiliation":[{"name":"Department of Medicine Mackenzie Evangelical School of Medicine Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-9925","authenticated-orcid":false,"given":"K. R.","family":"Chrisostomo","sequence":"additional","affiliation":[{"name":"Internal Medicine Post Graduate, Clinical Hospital Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. P.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Post Graduate, Clinical Hospital Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-8093","authenticated-orcid":false,"given":"R.","family":"Nisihara","sequence":"additional","affiliation":[{"name":"Internal Medicine Post Graduate, Clinical Hospital Federal University of Paran\u00e1  Curitiba Brazil"},{"name":"Department of Medicine Mackenzie Evangelical School of Medicine Paran\u00e1  Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"858","article-title":"Decreased resting metabolic rate among persons with Down Syndrome","volume":"199","author":"Allison D. B.","year":"1995","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0143-7"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1687-1"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-77"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00483.x"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.09.028"},{"key":"e_1_2_14_8_1","first-page":"13S","article-title":"Reproduction in Down syndrome","volume":"59","author":"Bovicelli L.","year":"1982","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2002.21.10.1087"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4133-x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2008.12.002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.01.028"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1352\/1934-9556-55.5.315"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2018.11.011"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2008.00020.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00025-9"},{"key":"e_1_2_14_17_1","first-page":"107","article-title":"Health conditions associated with aging and end of life of adults with Down syndrome. Int Rev Res","volume":"39","author":"Esbensen A. J.","year":"2010","journal-title":"Mental Retardation"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315751"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2017.04.020"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1443-7"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291532"},{"key":"e_1_2_14_22_1","first-page":"1","article-title":"National health and nutrition examination survey: Analytic guidelines, 1999\u20102010","volume":"161","author":"Johnson C. L.","year":"2013","journal-title":"Vital and Health Statistics"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-6-1332"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115215"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.9.990"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1586"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-7-4"},{"key":"e_1_2_14_28_1","first-page":"5","article-title":"International Physical Activity Questionnaire (lPAQ): Study of validity and reliability in Brazil","volume":"6","author":"Matsudo S.","year":"2012","journal-title":"Revista Brasileira de Atividade F\u00edsica and Sa\u00fade"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2109-4"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1053"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12523"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.6.837"},{"key":"e_1_2_14_33_1","first-page":"566","article-title":"Long bone growth in Down's syndrome","volume":"112","author":"Rarick G. L.","year":"1966","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<137::AID-DVDY1>3.0.CO;2-N"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01346.x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12608"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-021-00674-y"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1010-4"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2393-7"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17124273"},{"key":"e_1_2_14_41_1","first-page":"12","article-title":"Changes in bone mineral density in Down syndrome individuals: a systematic review and meta\u2010analysis","volume":"33","author":"Zhang Y.","year":"2021","journal-title":"Osteoporosis International"}],"container-title":["Journal of Intellectual Disability Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jir.13031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T10:47:13Z","timestamp":1692355633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jir.13031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jir.13031"],"URL":"https:\/\/doi.org\/10.1111\/jir.13031","archive":["Portico"],"relation":{},"ISSN":["0964-2633","1365-2788"],"issn-type":[{"value":"0964-2633","type":"print"},{"value":"1365-2788","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"assertion":[{"value":"2022-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}