{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:07:47Z","timestamp":1773162467938,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with Down syndrome (DS) frequently have concomitant clinical problems. There are no studies in the literature evaluating gross motor development and handgrip strength in the presence of congenital heart disease (CHD), which is one of the most common comorbidities in population with DS. The aim of this study was to compare cardiopulmonary parameters, gross motor development and handgrip strength in children with DS with and without CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 28 children with DS (14 with CHD and 14 without CHD) were evaluated. Demographic data and cardiopulmonary parameters were recorded. Gross motor development and handgrip strength were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with DS and CHD had lower GMFM\u201088 scores and right handgrip strength and higher Wang respiratory score than children with DS and no CHD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). GMFM\u201088 scores were moderately correlated with resting oxygen saturation (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.46, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and right handgrip strength (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.67, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripheral muscle strength and oxygen saturation may be factors affecting gross motor development in children with DS. From this point of view, evaluating cardiopulmonary parameters, motor development and handgrip strength in children with DS and CHD is important to identify risks, provide early intervention and support development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13092","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T06:27:22Z","timestamp":1695277642000},"page":"64-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of cardiopulmonary parameters, motor development and muscle strength in children with Down syndrome with and without congenital heart disease"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-1734","authenticated-orcid":false,"given":"T.","family":"Siyah","sequence":"first","affiliation":[{"name":"Faculty of Physiotherapy and Rehabilitation Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saglam","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Rehabilitation Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. V.","family":"Yagli","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Rehabilitation Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Ertugrul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. H.","family":"Aykan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Karagoz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2009.06.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1448"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2015.00710108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10332"},{"key":"e_1_2_10_7_1","first-page":"34","article-title":"Reliability and validity of the respiratory score in the assessment of acute bronchiolitis","volume":"11","author":"Chin H. 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