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The purposes of this study were (i) to compare the sensory processing patterns and gross motor function between children and adolescents with DS and with typical development (TD) and (ii) to explore associations between these areas in both DS and TD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This cross\u2010sectional study involved a sample size of 25 participants with DS (mean age 10.24\u00a0\u00b1\u00a02.04\u00a0years) and 25 participants with TD (mean age 10.04\u00a0\u00b1\u00a02.82\u00a0years). The sensory processing patterns were assessed using the Sensory Profile Second Version questionnaire, and the gross motor function was measured with the Gross Motor Function Measure (GMFM\u201088) dimensions (D) <jats:italic>standing<\/jats:italic>, and (E) <jats:italic>walking, running, and jumping<\/jats:italic>. Differences between groups were tested using the Mann\u2013Whitney test, and the relationship between the variables was examined using Spearman's correlation tests, with a significance level set at 5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with DS showed greater difficulties with sensory processing than TD children in Seeker (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Avoider (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Sensitivity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Registration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Auditory (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Touch (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), Movements (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), Oral (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), Conduct (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), Socioemotional (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and Attentional (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) domains. Additionally, children with DS presented lower gross motor function than TD in GMFM\u201088, <jats:italic>standing<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:italic>walking, running, and jumping<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Correlations were found between greater difficulties with sensory processing in Touch and lower gross motor function in <jats:italic>walking, running, and jumping<\/jats:italic> for the DS group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest there are more difficulties in sensory processing patterns and gross motor function in children with DS than in TD. Also, there is a single association between more difficulties in sensory processing and less well\u2010developed motor function in the DS group. Therefore, a comprehensive assessment of all these aspects should be performed in children and adolescents with DS, along with the provision of relevant interventions addressing specific needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13118","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T13:33:16Z","timestamp":1704547996000},"page":"358-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship between sensory processing patterns and gross motor function of children and adolescents with Down syndrome and typical development: a cross\u2010sectional study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-3123","authenticated-orcid":false,"given":"B. H.","family":"Brugnaro","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Child Development Analysis Laboratory (LADI) Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Pauletti","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Child Development Analysis Laboratory (LADI) Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. R. G.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Child Development Analysis Laboratory (LADI) Federal University of S\u00e3o Carlos (UFSCar)  S\u00e3o Carlos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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