{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:01:35Z","timestamp":1787166095321,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007453","name":"Stiftung VERUM","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      People with Down's syndrome (DS) are at high risk of developing Alzheimer dementia (DS\u2010AD) due to a triplication of the\n                      <jats:italic>amyloid precursor protein<\/jats:italic>\n                      gene. While several tools to diagnose and screen for DS\u2010AD, such as the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID), are available in English, validated German versions of such instruments are scarce.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A German version of the DSQIID questionnaire (DSQIID\u2010G) was completed by caregivers before attending our specialist outpatient department for DS\u2010AD. All participants were assessed blind to DSQIID\u2010G scoring using clinical and neuropsychological examinations, including the\n                      <jats:italic>Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities<\/jats:italic>\n                      (CAMDEX\u2010DS). ICD\u201010 and amyloid\/tau\/neurodegeneration (A\/T\/N) criteria were applied to detect and categorise cognitive decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 86 participants, 43 (50%) showed evidence of cognitive decline. A definite diagnosis of DS\u2010AD was reached in 17 (19.8%) and mild cognitive impairment in seven (8.3%) participants. Secondary causes of cognitive decline were determined among 13 (15.1%) participants, and in six (7%) cases, the diagnosis remained unclassifiable due to co\u2010morbidities. Compared with cognitively stable individuals, participants with cognitive decline (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043) displayed higher DSQIID\u2010G total scores [median (range): 3 (0\u201321) vs. 19 (0\u201348),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001]. A total score of &gt;7 provided a sensitivity of 0.94 against a specificity of 0.76, to discriminate DS\u2010AD and participants without cognitive decline according to ROC analysis. The convergent validity against the CAMDEX\u2010DS interview score was good (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.74), and split\u2010half reliability (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.96), internal consistency (Cronbach's \u03b1\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.96), test\u2013retest reliability (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.88) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a025) and interrater reliability (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.81) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031) were excellent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The DSQIID\u2010G showed excellent psychometric properties, including concurrent and internal validity and reliability. The cut\u2010off value for screening was lower than in the original English validation study. For a screening instrument like DSQIID\u2010G, a lower cut\u2010off is preferable to increase case detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jir.13144","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T03:50:00Z","timestamp":1715917800000},"page":"1146-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of a German version of the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID\u2010G) in Down's syndrome"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-7302","authenticated-orcid":false,"given":"G.","family":"Nuebling","sequence":"first","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disorders (DZNE), Site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Wagemann","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disorders (DZNE), Site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Faculty of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wlasich","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Loosli","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sandk\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stockbauer","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disorders (DZNE), Site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Prix","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Disorders (DZNE), Site Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.1997.tb00692.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0559-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.1999.043005400.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2007.00956.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.024984"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-95720-3_28"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-61720-6_11"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1026\/02803-000"},{"key":"e_1_2_9_10_1","volume-title":"Lehrbuch der psychologischen Diagnostik","author":"Fisseni H. 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