{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:45:14Z","timestamp":1759938314142,"version":"3.37.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/13864\u20106","2020\/07730\u20108"],"award-info":[{"award-number":["2014\/13864\u20106","2020\/07730\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Children with intellectual disability (ID) usually exhibit neuroendocrine functioning impairment, such as alterations in the hypothalamic\u2013pituitary\u2013adrenal (HPA) neuroendocrine axis, which can result in glucocorticoid cortisol release alterations. Indeed, many studies showed a positive association between ID and cortisol concentration. However, evidence is lacking on the relationship between child neurodevelopment and cortisol levels during adolescence in population\u2010based studies. We aimed to test the association between ID and hair cortisol concentration (HCC) during adolescence in a prospective population\u2010based cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 1770 individuals in the 2004 Pelotas Birth Cohort were used. ID was diagnosed at age 6 through clinical examination. Hair cortisol was measured at age 15. Association was assessed using linear regression models adjusted for sex, socio\u2010economic factors, hair\u2010related variables and corticosteroid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher HCC were observed in individuals with ID (<jats:italic>\u03b2<\/jats:italic>: 1.120; 95% CI: 1.012, 1.241) in the analysis adjusted for sex, hair\u2010related variables and corticosteroid use. Compared to the other aetiological groups, this was more evident in idiopathic ID. But this did not remain significant when demographics\/socio\u2010economic variables were controlled for.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with ID, particularly those with idiopathic ID, might exhibit dysfunction in the HPA axis or experience heightened stress levels during adolescence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13204","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T11:31:57Z","timestamp":1732707117000},"page":"214-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Intellectual Disability and Hair Cortisol Concentration in Adolescents in a Brazilian Population\u2010Based Birth Cohort"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-8240","authenticated-orcid":false,"given":"Karen\u00a0Y.","family":"S\u00e1nchez\u2010Luquez","sequence":"first","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"},{"name":"Post Graduate Program in Health Sciences S\u00e3o Francisco University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"de Menezes\u00a0Karam","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Public Health Federal University of Rio Grande  Rio Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aluisio\u00a0J.\u00a0D.","family":"Barros","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioural Neurosciences McMaster University  Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Murray","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"},{"name":"Human Development and Violence Research Centre (DOVE) Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel\u00a0O.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Matijasevich","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e1\u00a0S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Tovo\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Post Graduate Program of Epidemiology Federal University of Pelotas  Pelotas Brazil"},{"name":"Human Development and Violence Research Centre (DOVE) Federal University of Pelotas  Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2017.07.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22179"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076819890547"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100722.2007.00423.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/fam0000545"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944\u20107558\u2010125.5.353"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/24705470211047885"},{"issue":"2","key":"e_1_2_9_10_1","first-page":"2","article-title":"Estresse em um Fiode Cabelo: Revis\u00e3o Sistem\u00e1tica Sobre Cortisol Capilar","volume":"13","author":"Silva A. 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