{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:39:56Z","timestamp":1776415196701,"version":"3.51.2"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002368"],"award-info":[{"award-number":["TL1TR002368"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG083130"],"award-info":[{"award-number":["K01AG083130"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P20GM144269"],"award-info":[{"award-number":["P20GM144269"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resting metabolic rate (RMR), the energy required by the body at rest, is the largest part of total daily energy expenditure. Commonly used prediction equations may overestimate RMR in adults with Down syndrome (DS). The purpose of this study was to assess the equivalency of prediction equations for estimating RMR in adults with DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five adults with DS (24\u2009\u00b1\u20095\u2009years of age, 64% female) completed RMR assessments at an academic medical centre in the United States between November 2021 and July 2023. Measured RMR (kilocalories per day) was compared to estimated RMR from eight prediction equations using a null hypothesis significance (i.e., a paired <jats:italic>t<\/jats:italic>\u2010test) and equivalence (i.e., a two one\u2010sided test) tests. Bland\u2013Altman plots, Pearson correlations and linear regressions were used to evaluate the bias between the measured and predicted RMR values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Measured RMR in adults with DS was 1090\u2009\u00b1\u2009136\u2009kcal\/day. Prediction equations overestimated RMR by 8\u2009\u00b1\u200916% (76\u2009\u00b1\u2009165\u2009kcal\/day) to 45\u2009\u00b1\u200916% (488\u2009\u00b1\u2009165\u2009kcal\/day) except for the Bernstein fat\u2010free mass equation which underestimated RMR by 0.2\u2009\u00b1\u200911.5% (8\u2009\u00b1\u2009123\u2009kcal\/day) and was statistically equivalent to measured RMR in our sample (<jats:italic>p<\/jats:italic>\u2009=\u20090.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Bernstein fat\u2010free mass equation offers better accuracy in adults with DS than other RMR prediction equations, but the equation needs to be evaluated in larger, more diverse samples of adults with DS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13215","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:45:07Z","timestamp":1739252707000},"page":"428-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comparison of Commonly Used Prediction Equations for Estimating Resting Metabolic Rate in Adults With Down Syndrome"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-3581","authenticated-orcid":false,"given":"Brian\u00a0C.","family":"Helsel","sequence":"first","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center, Department of Neurology The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph\u00a0R.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Division of Physical Activity and Weight Management, Department of Internal Medicine The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-8105","authenticated-orcid":false,"given":"Amy\u00a0E.","family":"Bodde","sequence":"additional","affiliation":[{"name":"Division of Physical Activity and Weight Management, Department of Internal Medicine The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard\u00a0A.","family":"Washburn","sequence":"additional","affiliation":[{"name":"Division of Physical Activity and Weight Management, Department of Internal Medicine The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-1643","authenticated-orcid":false,"given":"Lauren\u00a0T.","family":"Ptomey","sequence":"additional","affiliation":[{"name":"Division of Physical Activity and Weight Management, Department of Internal Medicine The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"issue":"12","key":"e_1_2_8_2_1","first-page":"858","article-title":"Decreased Resting Metabolic Rate Among Persons With Down Syndrome","volume":"19","author":"Allison D. 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