{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T08:40:01Z","timestamp":1748594401441,"version":"3.41.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K18709"],"award-info":[{"award-number":["20K18709"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Using cumulative time spent with SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200990% (CT90) as an indicator, this retrospective observational study aimed to assess the incidence and severity of hypoxemia during deep intravenous sedation for patients with intellectual disabilities. Additionally, it intended to identify patient characteristics and anaesthesia\u2010related factors independently associated with CT90.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>The pulse oximetry data were collected every 5\u2009s during intravenous dental sedation in 144 patients with intellectual disabilities. Hypoxemia and severe hypoxemia were defined as SpO<jats:sub>2<\/jats:sub>\u2009&lt;\u200990% and CT90\u2009&gt;\u20091%, respectively. Multiple linear regression analysis was performed to identify independent risk indicators associated with the occurrence of hypoxemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than one episode of hypoxemia occurred in 62% (89\/144) of patients. CT90 was 1.9\u2009\u00b1\u20094.8% during sedation and severe hypoxemia developed in 35% (50\/144) of patients. BMI was a significant independent patient risk indicator for severe hypoxemia but accounted for only 28% of the variability in its incidence. Notably, the use of a BIS monitor, an appropriate dose of propofol and an extra suctioning device were identified as independent factors that could improve SpO<jats:sub>2<\/jats:sub> level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe hypoxemia frequently occurred during intravenous sedation, particularly in obese patients with intellectual disabilities. Technical and pharmacological improvements of sedation strategies are essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13232","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T05:46:32Z","timestamp":1742708792000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Obesity on Hypoxemia During Deep Dental Sedation for Paediatric and Adult Patients With Intellectual Disabilities: CT90 as an Outcome"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5816-0149","authenticated-orcid":false,"given":"Aki","family":"Kawauchi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Chiba University Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Dental Anesthesiology, Graduate School of Medical and Dental Science Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Graduate School of Medical and Dental Science Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Dentistry Saitama Rehabilitation Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Saitama Rehabilitation Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Graduate School of Medical and Dental Science Institute of Science Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiroh","family":"Isono","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chiba University Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2010.00136.x"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"7","article-title":"Intravenous Procedural Sedation: An Alternative in the Treatment of Patients With Intellectual Disability","volume":"9","author":"Barbieri C. 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