{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T03:10:04Z","timestamp":1750907404502,"version":"3.41.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001873","UL1 TR002373","UL1 TR001414","UL1 TR001857","UL1 TR002345"],"award-info":[{"award-number":["UL1 TR001873","UL1 TR002373","UL1 TR001414","UL1 TR001857","UL1 TR002345"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K99AG084738"],"award-info":[{"award-number":["K99AG084738"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD007489"],"award-info":[{"award-number":["T32HD007489"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adults with Down syndrome (DS) have an elevated risk and early age of onset for Alzheimer's disease (<jats:sc>AD<\/jats:sc>). To support upcoming clinical <jats:sc>AD<\/jats:sc> trials, there is a critical need to establish cognitive outcome measures that can be used to capture intervention effects. One measure that has successfully been used to detect <jats:sc>AD<\/jats:sc>\u2010related cognitive decline in the DS population is a measure of episodic memory, the modified Cued Recall Test (mCRT). Demonstrated utility of the mCRT warrants further investigation into comparisons between the A and B versions, free versus cued recall and changes in performance over time to better understand sensitivity for tracking memory decline over time based on age and <jats:sc>AD<\/jats:sc> clinical status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants were 272 adults with DS aged 25\u201381 (mean age\u2009=\u200943.12\u2009years, SD\u2009=\u20099.79). Study procedures were completed at three cycles of data collection: baseline, 16\u2010month follow\u2010up and 32\u2010month follow\u2010up. Participants were enrolled in the Alzheimer Biomarker Consortium\u2013Down Syndrome longitudinal study and completed the mCRT as part of a multiday evaluation. Comparisons were made between the A and B versions of the mCRT in recall and intrusion scores. Participants' ratio of free relative to cued recall was also examined at baseline and longitudinally. Participant performance was compared by age group, clinical <jats:sc>AD<\/jats:sc> status (cognitively stable [CS], mild cognitive impairment [MCI] or <jats:sc>AD<\/jats:sc> dementia) and premorbid level of intellectual disability (ID).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Version differences were identified, with the most salient differences in the moderate and severe\/profound ID groups. The mCRT free recall declined with age in CS participants. Free and cued recall scores were lower in those with MCI and <jats:sc>AD<\/jats:sc> dementia, with the exception of the mild ID MCI group, whose cued recall scores were not significantly different from the CS group. Decline across 32\u2009months (mCRT total score decline of 1.29 points\/year) was observed for CS participants beginning at \u2265\u200950\u2009years old, with more pronounced declines in adults with DS with an MCI or <jats:sc>AD<\/jats:sc> dementia diagnosis (3.36 and 4.20 points\/year, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Characterising test version differences and participant free versus cued recall performance on the mCRT is important for understanding performance under testing conditions and to maximise the sensitivity of clinical interventions to capture meaningful effects. Our findings suggest that clinical <jats:sc>AD<\/jats:sc> trials for DS should be cautious about using both versions of the mCRT. Examining the profile of free relative to cued recall may enhance sensitivity for detecting treatment benefits for adults with DS across the range of premorbid ID levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13237","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T05:57:07Z","timestamp":1745215027000},"page":"569-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-339X","authenticated-orcid":false,"given":"Emily\u00a0K.","family":"Schworer","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2010Madison Waisman Center  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin\u00a0L.","family":"Handen","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Department of Psychiatry  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Krinsky\u2010McHale","sequence":"additional","affiliation":[{"name":"New York State Institute for Basic Research in Developmental Disabilities  Staten Island New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy\u00a0L.","family":"Hom","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel\u00a0C.\u00a0H.","family":"Clare","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan\u00a0P.","family":"Harp","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Kentucky College of Medicine  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret\u00a0B.","family":"Pulsifer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mapstone","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Irvine School of Medicine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Head","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of California, Irvine School of Medicine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley\u00a0T.","family":"Christian","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison Waisman Center  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-6282","authenticated-orcid":false,"given":"Sigan\u00a0L.","family":"Hartley","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison Waisman Center  Madison Wisconsin USA"},{"name":"School of Human Ecology University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Alzheimer Biomarker Consortium\u2010Down Syndrome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001064\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-120.6.481"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1754470X22000484"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00408-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200817"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/15.6.529"},{"volume-title":"The Cued Recall Test: Detectin of Memory Impairment","year":"2009","author":"Devenny D. A.","key":"e_1_2_9_8_1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2788.2002.00417.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-122.3.247"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30285-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00245-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565648709540361"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.6.900"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01652.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.12.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12065"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11091128"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12256"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11091220"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.12910"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12361"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12957"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12582"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12444"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.25573"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13444"}],"container-title":["Journal of Intellectual Disability Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jir.13237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:33:51Z","timestamp":1750905231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jir.13237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jir.13237"],"URL":"https:\/\/doi.org\/10.1111\/jir.13237","archive":["Portico"],"relation":{},"ISSN":["0964-2633","1365-2788"],"issn-type":[{"type":"print","value":"0964-2633"},{"type":"electronic","value":"1365-2788"}],"subject":[],"published":{"date-parts":[[2025,4,20]]},"assertion":[{"value":"2024-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}