{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:15:28Z","timestamp":1780550128088,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Down syndrome (DS) stands as the most frequent chromosomal abnormality leading to intellectual disability. A prevalence rate of 6.1\u201313.1 per 10\u2009000 births has been estimated. Although life expectancy has been increasing from 25\u2009years in 1983 to 60\u2009years in 2020 in this population, their quality may be impaired by the development of diseases. However, it has also opened the possibility of carrying out a significant number of cardiovascular risk studies in DS. This includes comparisons of biochemical cardiometabolic risk factors, including total cholesterol (TC), triglycerides (TG), high\u2010density lipoprotein cholesterol (HDL\u2010C) and low\u2010density lipoprotein cholesterol (LDL\u2010C), between normal\u2010weight children with DS and age\u2010 and gender\u2010matched children without DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, with parental consent, 25 children with DS and 30 age\u2010matched controls (8\u201312\u2009years old) participated. Body mass index (BMI) was calculated from anthropometric assessments, while glucose and lipid profiles were measured from the obtained blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the World Health Organization BMI criteria, all individuals from both groups had normal weight. The DS group exhibited higher TC (179.4\u2009\u00b1\u200950.4\u2009mg\/dL vs. 120.7\u2009\u00b1\u200931.6\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.000), TG (125.2\u2009\u00b1\u200942.5\u2009mg\/dL vs. 86.5\u2009\u00b1\u200954.1\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005) and LDL\u2010C (108.1\u2009\u00b1\u200940.8\u2009mg\/dL vs. 120.8\u2009\u00b1\u200953.5\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.373), while HDL\u2010C was lower (46.3\u2009\u00b1\u200912.3\u2009mg\/dL vs. 54.7\u2009\u00b1\u200911.8\u2009mg\/dL, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) compared with the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that children with DS have a higher prevalence of cardiometabolic risk factors compared with the general population, regardless of weight, highlighting the importance of studying dyslipidaemias in the DS population independently of body weight.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13241","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:31:17Z","timestamp":1744605077000},"page":"605-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Cardiometabolic Risk Factors in Children With Down Syndrome With Normal Weight: A Comparative Study Against a Non\u2013Down Syndrome Cohort"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-9061","authenticated-orcid":false,"given":"Kenia","family":"Esparza\u00a0Ocampo","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Biom\u00e9dicas, Facultad de Ciencias Qu\u00edmico\u2010Biol\u00f3gicas Universidad Aut\u00f3noma de Sinaloa  Culiac\u00e1n Sinaloa 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