{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:05:48Z","timestamp":1792577148799,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15HD098660"],"award-info":[{"award-number":["R15HD098660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The estimation of physical activity (PA) and sedentary behaviour with accelerometers is typically based on the relationship between accelerometer output and metabolic equivalents (METs)\u2014an index of PA intensity. But for adults with Down syndrome (DS), PA intensity may be better reflected in the percent oxygen uptake reserve (%VO<jats:sub>2Reserve<\/jats:sub>), as it accounts for their lower aerobic fitness. This study examined if the relationship between accelerometer output and METs or %VO<jats:sub>2Reserve<\/jats:sub> across various PAs and sedentary behaviours differs between adults with and without DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one adults with DS (age 35\u2009\u00b1\u20099\u2009years; 18 women) and 41 adults without DS (age 24\u2009\u00b1\u20095\u2009years; 18 women) performed 17 tasks of varying intensity. We estimated aerobic fitness with a submaximal treadmill test. We measured oxygen uptake with portable calorimetry and expressed it as METs and %VO<jats:sub>2Reserve<\/jats:sub>. Output from triaxial accelerometers on the nondominant hip and wrist was determined as Vector Magnitude (VM). We used multilevel modelling to evaluate the relationships of METs or %VO<jats:sub>2Reserve<\/jats:sub> with VM, controlling for body mass index (BMI) and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the hip accelerometer, VM and the group\u2010by\u2010VM interaction significantly predicted METs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; conditional <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.82), but between\u2010group differences were small. For the wrist accelerometer, VM and age significantly predicted METs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.035; conditional <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.76). For both the hip and the wrist accelerometer, VM, the group\u2010by\u2010VM interaction and BMI significantly predicted %VO<jats:sub>2Reserve<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.047; conditional <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.82 and 0.74, respectively). Between\u2010group differences in the response to VM were larger for VO<jats:sub>2Reserve<\/jats:sub> than METs models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relationship between accelerometer output and %VO<jats:sub>2Reserve<\/jats:sub> across PAs and sedentary behaviours is different between adults with and without DS. Calibrating accelerometer output against %VO<jats:sub>2Reserve<\/jats:sub> may be preferable to METs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.13253","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:36:18Z","timestamp":1747726578000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerometer Output and Oxygen Uptake in Adults With and Without Down Syndrome: METs vs. Percent VO<sub>2Reserve<\/sub>"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-219X","authenticated-orcid":false,"given":"S.","family":"Agiovlasitis","sequence":"first","affiliation":[{"name":"Department of Kinesiology Mississippi State University  Starkville 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u00a0W.","family":"Motl","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.13002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jar.12659"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.03.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820936c4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1123\/apaq.29.2.179"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1706648"},{"key":"e_1_2_10_8_1","volume-title":"ACSM'S Guidelines for Exercise Testing and Prescription","author":"American 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