{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T01:10:10Z","timestamp":1778289010961,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autism spectrum disorder (ASD) is common in Down syndrome (DS). There are no standardised screening\/assessment tools for evaluating ASD in DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilised a novel validated questionnaire, the ND\u2010PROM, to investigate differences in developmental skills and behaviours among children with DS only, ASD only and DS\u2009+\u2009ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data analysis using ANOVA tests and post hoc <jats:italic>t<\/jats:italic>\u2010tests revealed item\u2010level differences between groups in domains specific to ASD (nonverbal communication, social\u2013emotional understanding, social interaction, independent play, restrictive and repetitive behaviours and interests and sensory processes) and not specific to ASD (expressive language, receptive language, adaptive\/toileting, challenging behaviours, mental health and impulse\/ADHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ASD\u2010specific symptoms best distinguished DS only and DS\u2009+\u2009ASD groups, while non\u2010ASD symptoms best distinguished ASD only and DS\u2009+\u2009ASD groups. Items that best differentiate groups are presented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jir.70015","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T10:55:08Z","timestamp":1752576908000},"page":"809-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurobehavioural Patterns in the Diagnosis of Autism Spectrum Disorder in Down Syndrome"],"prefix":"10.1111","volume":"69","author":[{"given":"Lina\u00a0R.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Psychiatry Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics Ann &amp; Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Anzueto","sequence":"additional","affiliation":[{"name":"Dan L Duncan Children's Neurodevelopmental Center at the Children's Learning Institute, Department of Pediatrics McGovern Medical School at the University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Olsen","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Health, Section of Psychology Children's Mercy University of Missouri \u2010 Kansas City, School of Medicine  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-734X","authenticated-orcid":false,"given":"Katherine","family":"Pawlowski","sequence":"additional","affiliation":[{"name":"Division of Developmental Medicine Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan\u00a0D.","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology, Department of Pediatrics Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Department of Neurology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Sideridis","sequence":"additional","affiliation":[{"name":"Division of Developmental Medicine Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-7670","authenticated-orcid":false,"given":"Noemi","family":"Spinazzi","sequence":"additional","affiliation":[{"name":"UCSF Benioff Children's Hospital Oakland  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole\u00a0T.","family":"Baumer","sequence":"additional","affiliation":[{"name":"Division of Developmental Medicine and Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/dbp.0000000000000996"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1243467"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1293937"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010022\u201000530\u20105"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"1","article-title":"Patterns of Autism Spectrum Symptomatology in Individuals With Down Syndrome Without Comorbid Autism Spectrum Disorder","volume":"7","author":"Channell M. 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