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Among adults with DS, those with congenital heart disease (CHD) have lower physical activity than those without CHD. Many trials exclude people with CHD from exercise trials; thus, the safety and effectiveness of these interventions for increasing physical activity and fitness in adults with DS and CHD are not known. The purpose of this analysis was to evaluate the safety and preliminary effectiveness of an exercise intervention in adults with DS and CHD for increasing physical activity and fitness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This secondary analysis used data from a 12\u2010month randomized controlled physical activity intervention for adults with DS. Safety of the intervention was assessed as number and severity of adverse events and compared by CHD status. Changes in physical activity (accelerometry) and fitness (VO\n                      <jats:sub>2peak<\/jats:sub>\n                      ) among those with CHD were evaluated using mixed effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six participants had CHD and were randomized to one of the exercise intervention arms (average age 25.5\u2009years, 55.6% female). There were no differences in number (CHD: 18 vs. no CHD 22 events; rate ratio 1.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94) or severity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25) of adverse events between those with and without CHD. Participants significantly increased moderate\u2010to\u2010vigorous physical activity minutes per day (+8.6\u2009min\/day,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045) and VO\n                      <jats:sub>2peak<\/jats:sub>\n                      (+2.1\u2009mL\/kg\/min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Results from this analysis show preliminary support for young adults with DS and CHD to safely participate in exercise interventions that are appropriately designed for their inclusion. These interventions also demonstrate preliminary effectiveness for increasing physical activity and fitness. Findings should be repeated and confirmed in a larger, more diverse sample to understand the safety and impact of exercise on health in persons with DS and CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jir.70087","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:53:49Z","timestamp":1770166429000},"page":"491-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-5644","authenticated-orcid":false,"given":"Julianne\u00a0G.","family":"Clina","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas 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City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-6509","authenticated-orcid":false,"given":"Daniel\u00a0E.","family":"Forsha","sequence":"additional","affiliation":[{"name":"Ward Family Heart Center Children's Mercy Kansas City  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica\u00a0C.","family":"Danon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-8105","authenticated-orcid":false,"given":"Amy\u00a0E.","family":"Bodde","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas City Kansas 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