{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:03:48Z","timestamp":1790042628632,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sleep\u2010disordered breathing (SDB) frequently complicates Down syndrome (DS). Beyond upper airway obstruction, emerging evidence suggests an autonomic nervous system (ANS) dysfunction affecting CO\n                      <jats:sub>2<\/jats:sub>\n                      regulation. The aim of this study was to investigate nocturnal gas exchanges in children with DS and compare them to what has been observed in typically developing (TD) children, describe clinical signs of SDB and ANS dysfunction, executive functioning and motor skills and explore potential associations between PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      levels and neuropsychological outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective study, children with DS aged 4\u201316\u2009years without previously identified obstructive sleep apnoea were recruited between October 2019 and March 2022. Clinical assessment, autonomic symptom, executive function questionnaires and home overnight transcutaneous oxycapnography were performed; children with symptoms and\/or elevated PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      underwent polysomnography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight children with DS (median age: 8.0 [7.0\u201312.0] years) were included, of whom 30 had interpretable overnight SpO\n                      <jats:sub>2<\/jats:sub>\n                      and PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      recordings. Median mean nocturnal PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      was 44 [40\u201346] mmHg, significantly higher than in TD children (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), including in the subgroup with no or mild OSA (45 [41.5\u201346] mmHg). The most frequent clinical signs of SDB were restless sleep (62%), concentration difficulties (54%) and snoring (48%), whereas ophthalmic (51%) and digestive (46%) symptoms of autonomic dysfunction were common. No association was found between nocturnal PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      and executive functioning or motor skills.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Children with DS exhibit higher nocturnal PtcCO\n                      <jats:sub>2<\/jats:sub>\n                      levels than TD children, along with clinical features suggestive of dysautonomia, supporting the hypothesis of a global ANS dysfunction affecting chemosensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jir.70180","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:19:42Z","timestamp":1790039982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Nocturnal CO\n                    <sub>2<\/sub>\n                    and Autonomic Dysfunction in Children With Down Syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-3880","authenticated-orcid":false,"given":"Jessica","family":"Taytard","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Department Armand Trousseau Hospital, AP\u2010HP Sorbonne University  Paris France"},{"name":"Respiratory Physiology and Sleep Unit Armand Trousseau Hospital, AP\u2010HP, Sorbonne University  Paris France"},{"name":"INSERM UMR\u2010S 1158 \u201cNeurophysiologie Respiratoire Exp\u00e9rimentale et Clinique\u201d, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segol\u00e8ne","family":"Falquero","sequence":"additional","affiliation":[{"name":"Institut J\u00e9r\u00f4me Lejeune  Paris 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