{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:44:36Z","timestamp":1791942276632,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J intellect Disabil Res"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory disorders are frequent in children with Down syndrome (DS), causing prolonged hospitalisations and increased healthcare system costs. Among these, recurrent wheezing is common in these children despite indications of lower rates of allergic sensitisation and asthma. This discrepancy is concerning because wheezing is often misinterpreted as asthma, leading to inappropriate treatment. Therefore, this study compared the profiles of allergic sensitisation among children with wheezing with and without DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study retrospectively reviewed medical records of children (2\u201312\u2009years) with recurrent wheezing, comparing 98 with DS (cases) and 96 without DS (controls). Clinical variables (pneumonia episodes, respiratory hospitalisations), biological markers (serum total IgE, eosinophil counts) and aeroallergen sensitisation (skin prick tests and\/or specific IgE) were analysed. Multivariate logistic regression was used to calculate adjusted odds ratios (OR). We analysed 194 children aged 2\u201312\u2009years with recurrent wheezing, including 98 with DS (cases) and 96 without (controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Allergic sensitisation was less prevalent in children with DS (7.1%) than in the control group (59.3%). Analysis revealed that DS was a protective factor, indicating that children with DS were 95% less likely to be sensitised than those without DS. Additionally, children with DS had significantly lower eosinophil counts and total IgE levels. Among sensitised children, allergic profiles were similar between groups, with\n                      <jats:italic>Dermatophagoides farinae<\/jats:italic>\n                      as the most common allergen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings support the hypothesis of a non\u2010allergic wheezing phenotype in children with DS, highlighting the need for individualised, precision\u2010based management to optimise respiratory care in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jir.70191","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:50:59Z","timestamp":1791939059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Allergic Sensitisation in Wheezing Children With Down Syndrome: A Case\u2013Control Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3436-5337","authenticated-orcid":false,"given":"Francylene Malheiros Macedo da Cunha","family":"Rego","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-7586","authenticated-orcid":false,"given":"Ge\u00f3rgia Veras de Ara\u00fajo Gueiros","family":"Lira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-6274","authenticated-orcid":false,"given":"Emanuel S\u00e1vio Cavalcanti","family":"Sarinho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-6642","authenticated-orcid":false,"given":"Patricia Gomes de Matos","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2673-6708","authenticated-orcid":false,"given":"Marcilio Lins","family":"Aroucha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5855-6359","authenticated-orcid":false,"given":"Igor Gabriel Araujo","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-5762","authenticated-orcid":false,"given":"Decio Medeiros","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco (UFPE)  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1007\/s11356-019-07234-z","article-title":"Aeroallergen Sensitization in Lebanese Asthmatic Children: The Results of a National Cohort Study","volume":"27","author":"Abiad H. 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Lung Cellular and Molecular Physiology"},{"key":"e_1_2_10_10_1","first-page":"2174","article-title":"The Prevalence of Lower Airway Anomalies in Children With Down Syndrome Compared to Controls","volume":"55","author":"DeLausnay M.","year":"2020","journal-title":"Pediatric Pulmonology"},{"issue":"8","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/pai.12796","article-title":"Lower Percentage of Allergic Sensitization in Children With Down Syndrome","volume":"28","author":"Eijsvoogel N. B.","year":"2017","journal-title":"Pediatric Allergy and Immunology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1007\/s00431-022-04634-1","article-title":"Increased Rate of Respiratory Symptoms in Children With Down Syndrome: A 2\u2010Year Web\u2010Based Parent\u2010Reported Prospective Study","volume":"181","author":"Eijsvoogel N. 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