{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:17:54Z","timestamp":1789035474851,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Japan Journal Nursing Sci"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the effect of home\u2010based exercise on motor symptoms (MS), non\u2010motor symptoms (NMS), and health\u2010related quality of life (HRQOL) in Parkinson\u02bcs disease (PD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a randomized control trial with a convenience sample of 98 PD patients. Data were collected at baseline and interventions after 4 and 8\u2009weeks. The exercise group was instructed to perform 150\u2009min\/week of exercise at home; the control group maintained their regular lifestyle. Questionnaires measured MS, NMS, and HRQOL. We also compare compliance and non\u2010compliance subgroups of the exercise group. The generalized estimating equation (GEE) was used to determine the exercise effect of 120 and 150\u2009min per week after testing for exercise times was at six time points (90\u2013140\u2009min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The exercise (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) and control groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) were homogeneous except for disease stage at baseline. Significant differences were found for depression, HRQOL, motor ability, activity of daily living, and fatigue (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.000) between the exercise and control groups, and also between the compliance and non\u2010compliance subgroups (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.05). The GEE revealed that exercising 150\u2009min\/week significantly improved HRQOL, depression, motor ability, ADL, fatigue, and sleep quality (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), though not anxiety, and exercising 120\u2009min\/week was also effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This home\u2010based exercise was effective in improving MS, NMS, and HRQOL. We recommend PD patients to exercise 30\u201350\u2009min at least three times a week, or 10\u201315\u2009min per session daily, to accumulate 120\u2013150\u2009min per week.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jjns.12418","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T06:35:28Z","timestamp":1618900528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of home\u2010based exercise on motor, non\u2010motor symptoms and health\u2010related quality of life in Parkinson\u02bcs disease patients: A randomized controlled trial"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-5682","authenticated-orcid":false,"given":"Pei\u2010Ling","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nursing, School of Nursing, College of Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Chung Shan Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shey\u2010Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh\u2010Hou","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsia\u2010Sui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Medicine Chang Gung University  Tao\u2010Yuan Taiwan"},{"name":"Healthy Aging Research Center Chang Gung University  Tao\u2010Yuan Taiwan"},{"name":"Department Dementia Center Chang Gung Memorial Hospital  Linkou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171173"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12208"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28009"},{"key":"e_1_2_11_5_1","unstructured":"American College of Sport Medicine(2011).ACSM issues new recommendations on quantity and quality of exercise. 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