{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:57:30Z","timestamp":1768640250293,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Japan Journal Nursing Sci"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of herbal agents in the prevention and therapy of radiodermatitis in breast cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized controlled trials were searched from databases such as PubMed, Web of Science, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) to assess the effectiveness of herbal agents compared to a standard medication or placebo in prevention or treatment of radiodermatitis in breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 16 studies involving 1994 patients were included. This meta\u2010analysis included 10 clinical trials of 562 breast cancer patients treated with calendula, silymarin, or aloe vera for the prevention of radiodermatitis. Silymarin showed positive effects in ameliorating the damage of radiodermatitis, whereas the efficacy of calendula and aloe vera in the treatment of radiodermatitis lacks sufficient evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Herbal medicine may show therapeutic effects on radiodermatitis in breast cancer, but more comprehensive investigations and clinical trials are required in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jjns.12559","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:37:43Z","timestamp":1696991863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-8256","authenticated-orcid":false,"given":"Suyun","family":"Que","sequence":"first","affiliation":[{"name":"Dali Bai Autonomous Prefecture People's Hospital  Dali China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanlei","family":"Ma","sequence":"additional","affiliation":[{"name":"Dali Bai Autonomous Prefecture People's Hospital  Dali China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Dali Bai Autonomous Prefecture People's Hospital  Dali China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangtao","family":"He","sequence":"additional","affiliation":[{"name":"Dali Bai Autonomous Prefecture People's Hospital  Dali China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.22034\/APJCP.2017.18.4.1139"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00519-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-011-2204-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2009.04.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02737863"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-711"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-57"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5704"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5857"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200212000-00007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2014.12.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/312072"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666210405093236"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6231"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S109763"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9481413"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.10.036"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1015296607061"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1518-8345.2035.2929"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.063"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.102205"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2005.04.013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i4.493"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5345"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2012.11.003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13434"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0186-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.44785"},{"issue":"8","key":"e_1_2_9_30_1","first-page":"1338","article-title":"Clinical evaluation of safety and efficacy of Boswellia\u2010based cream for prevention of adjuvant radiotherapy skin damage in mammary carcinoma: A randomized placebo controlled trial","volume":"19","author":"Togni S.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.067"},{"key":"e_1_2_9_32_1","unstructured":"Wang H. Y.(2018).Observation on the effect of fresh aloe vera in preventing breast cancer radiation dermatitis 88) p. 202\u2013202 (in Chinese)."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103932"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1622-5"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S305033"}],"container-title":["Japan Journal of Nursing Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jjns.12559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T02:06:21Z","timestamp":1705716381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jjns.12559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/jjns.12559"],"URL":"https:\/\/doi.org\/10.1111\/jjns.12559","archive":["Portico"],"relation":{},"ISSN":["1742-7932","1742-7924"],"issn-type":[{"value":"1742-7932","type":"print"},{"value":"1742-7924","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12559"}}