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Tissue slices from the mid\u2010cervix and near the external orifice of the cervix were analyzed in both two\u2010dimensions (2D) and three\u2010dimensions (3D). We validate that the cervical microstructure can be quantitatively assessed in three dimensions using FT\u2010SHG imaging and observe collagen fibers oriented both in and out\u2010of\u2010plane in the outermost and the innermost layers, which cannot be observed using 2D FT\u2010SHG analysis alone. This approach has the potential to be a clinically applicable method for measuring progressive changes in collagen organization during cervical remodeling in humans.<\/jats:p>","DOI":"10.1111\/jmi.12046","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T15:03:36Z","timestamp":1366383816000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Application of Fourier transform\u2010second\u2010harmonic generation imaging to the rat cervix"],"prefix":"10.1111","volume":"251","author":[{"given":"T.Y.","family":"LAU","sequence":"first","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana, Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.K.","family":"SANGHA","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana, Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.K.","family":"CHIEN","sequence":"additional","affiliation":[{"name":"Alpert Medical School of Brown University and Women and Infants Hospital of Rhode Island, Providence  Rhode Island U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.L.","family":"MCFARLIN","sequence":"additional","affiliation":[{"name":"Department of Women, Children and Family Health Science University of Illinois at Chicago  Chicago Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"WAGONER JOHNSON","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana, Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"JR.","given":"K.C.","family":"TOUSSAINT","sequence":"additional","affiliation":[{"name":"Department of Mechanical Science and Engineering University of Illinois at Urbana\u2010Champaign  Urbana, Illinois U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"026020\u20101\u201310","article-title":"Second harmonic generation imaging as a potential tool for staging pregnancy and predicting preterm birth","volume":"15","author":"Akins M.L.","year":"2010","journal-title":"J. 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