{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:11:36Z","timestamp":1784131896420,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Microscopy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As electron microscopes became more costly, technically complex, and integral to a wide range of scientific fields, centralised electron microscopy (EM) core facilities have become essential for maintaining accessibility, performance, and quality. Drawing on the experiences of running two EM core facilities in Finland, we outline key considerations for establishing and operating a biological and biomedical EM facility. We cover facility infrastructure and technical requirements, user training, sample preparation, safety and occupational considerations, personnel and cost management, and finish by outlining three areas, sustainability, research data management, and artificial intelligence, that we consider to be increasingly defining the strategic direction of EM facilities. By distinguishing the specific requirements of EM from those of light microscopy, this article provides practical guidance to support efficient, safe, and high\u2010quality facility operations within institutional and national imaging networks.<\/jats:p>","DOI":"10.1111\/jmi.70088","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:40:47Z","timestamp":1776087647000},"page":"346-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Running an electron microscopy core facility"],"prefix":"10.1111","volume":"302","author":[{"given":"Ilkka","family":"Miinalainen","sequence":"first","affiliation":[{"name":"Biocenter Oulu Electron Microscopy Laboratory University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-6934","authenticated-orcid":false,"given":"Eija","family":"Jokitalo","sequence":"additional","affiliation":[{"name":"Electron Microscopy Unit Institute of Biotechnology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Anderson K. &Munck S.(Guest Eds) (2024)Special issue: light microscopy core facility management.journal of microscopy 294(3) 251\u2013447."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1302680"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2017.07.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.960940"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13301"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-19723-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109509"},{"key":"e_1_2_11_9_1","volume-title":"Cell and tissue ultrastructure, a functional perspective","author":"Cross P. C.","year":"1993"},{"key":"e_1_2_11_10_1","volume-title":"Functional ultrastructure, atlas of tissue biology and pathology","author":"Pavelka M.","year":"2005"},{"key":"e_1_2_11_11_1","volume-title":"Histology, a text and atlas","author":"Ross M. H.","year":"2003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003498551"},{"key":"e_1_2_11_13_1","unstructured":"Sorenson R. L. &Brelje T. C.Histology Guide: A virtual microscopy laboratory. University of Minnesota Minneapolis. Available fromhttps:\/\/www.histologyguide.com"},{"key":"e_1_2_11_14_1","unstructured":"FAIRsharing.org: Electron Microscopy Image Library of Wild\u2010Type Mouse Tissues.FAIRsharing.https:\/\/doi.org\/10.25504\/FAIRsharing.20fe82"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2013.04.011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","unstructured":"Kirchenbuechler D. Deniz M. &Arvanitis C.(2025).Trail\u2013blazing and keeping pace: Building retaining and expanding image analysis expertise at a microscopy core facility.Frontiers in Bioinformatics 5 1613866.","DOI":"10.3389\/fbinf.2025.1613866"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","unstructured":"Schmidt C. Boissonnet T. Dohle J. Bernhardt K. Ferrando\u2010May E. Wernet T. Nitschke R. Kunis S. &Weidtkamp\u2010Peters S.(2024).A practical guide to bioimaging research data management in core facilities.Journal of Microscopy 294(3) 350\u2013371.","DOI":"10.1111\/jmi.13317"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","unstructured":"Soltwedel J. R. &Haase R.(2024).Challenges and opportunities for bioimage analysis core\u2010facilities.Journal of Microscopy 294(3) 338\u2013349.","DOI":"10.1111\/jmi.13192"},{"key":"e_1_2_11_19_1","unstructured":"Euro\u2010BioImaging ERIC. Euro\u2010BioImaging: The gateway to European biological and biomedical imaging.https:\/\/www.eurobioimaging.eu"},{"key":"e_1_2_11_20_1","unstructured":"Global BioImaging. Global BioImaging: The international network of cutting\u2010edge bioimaging facilities and communities. Hosted at EMBL Heidelberg Germany.https:\/\/www.globalbioimaging.org"},{"key":"e_1_2_11_21_1","unstructured":"BioImaging North America (BINA). BioImaging North America: Connecting empowering and giving a unified voice to the bioimaging community to advance science. Morgridge Institute for Research Madison Wisconsin USA.https:\/\/www.bioimagingnorthamerica.org"},{"key":"e_1_2_11_22_1","unstructured":"Jokitalo E.(2020). Remote access to Finnish Advanced Microscopy node.Euro\u2010BioImaging News Article 22.6.2020."},{"key":"e_1_2_11_23_1","volume-title":"Biosafety in the laboratory: Prudent practices for handling and disposal of infectious materials","author":"National Research Council","year":"1989"},{"key":"e_1_2_11_24_1","unstructured":"Association of Clinical Electron Microscopists (ACEM). ACEM: Promoting awareness teaching and best practice of clinical electron microscopy. RoyalMicroscopical Society UKhttps:\/\/www.acem.org.uk(accessed 7 April 2026)"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3400"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2020.00047"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/dfv054"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.12211"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-020-01846-0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/v7020666"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231197128"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13304"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13307"},{"key":"e_1_2_11_34_1","unstructured":"University of Liverpool (2023). Research Technical Professional Career Pathway. University of Liverpool Liverpool UK.https:\/\/www.liverpool.ac.uk\/research\/research\u2010environment\/enabling\u2010environment\/research\u2010technical\u2010pathway"},{"key":"e_1_2_11_35_1","unstructured":"The TALENT Commission (2022). The TALENT Commission Report: Technical skills roles and careers in UK higher education and research. UK Institute for Technical Skills & Strategy (UK ITSS) Midlands Innovation.https:\/\/itss.org.uk\/talent\u2010legacy\/talent\u2010commission\u2010report(accessed 7 April 2026)"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13246"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13316"},{"key":"e_1_2_11_38_1","unstructured":"University College London (2018). LEAF: Laboratory Efficiency Assessment Framework. Sustainable UCL University CollegeLondon London UK.https:\/\/www.ucl.ac.uk\/sustainable\/take\u2010action\/staff\u2010action\/leaf\u2010laboratory\u2010efficiency\u2010assessment\u2010framework"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.13317"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01381-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00131-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-00957-5"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbaf021"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/mam\/ozaf048.1088"}],"container-title":["Journal of Microscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmi.70088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jmi.70088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmi.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:55:46Z","timestamp":1784130946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmi.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jmi.70088"],"URL":"https:\/\/doi.org\/10.1111\/jmi.70088","archive":["Portico"],"relation":{},"ISSN":["0022-2720","1365-2818"],"issn-type":[{"value":"0022-2720","type":"print"},{"value":"1365-2818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2026-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}