{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:55:57Z","timestamp":1740124557137,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,12]],"date-time":"2013-01-12T00:00:00Z","timestamp":1357948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Division of Scientific Resources","award":["Y1-AI-0681-02"],"award-info":[{"award-number":["Y1-AI-0681-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 is an immunomodulatory agent that reduces lymphocytes in peripheral tissues and circulation. Such agents may be effective as vaginal microbicides for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> prevention. Systemic or vaginal application of <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 may reduce lymphocyte concentrations in genital tissues, reducing <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> target cell numbers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five female pigtail macaques received topical vaginal gel <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 (n\u00a0=\u00a02), intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 (n\u00a0=\u00a02), or placebo gel (n\u00a0=\u00a01) in this pilot study. Circulating and mucosal lymphocytes and genital mucosa, cytokines, and tissue histology were analyzed to document topical and <jats:styled-content style=\"fixed-case\">IV FTY<\/jats:styled-content>720 effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical and <jats:styled-content style=\"fixed-case\">IV FTY<\/jats:styled-content>720 appeared to decrease the levels of cervicovaginal <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101ra, and genital inflammatory cells. Small sample size precluded statistical analysis. Topical administration had no overt adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study introduces <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 as an immunomodulatory agent for the vaginal mucosa, compares topical effects to those of <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> administration, and provides the basis for future studies involving <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720 for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12033","type":"journal-article","created":{"date-parts":[[2013,1,13]],"date-time":"2013-01-13T01:50:43Z","timestamp":1358041843000},"page":"89-100","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the lymphocyte trafficking drug <scp>FTY<\/scp>720 in vaginal tissues"],"prefix":"10.1111","volume":"42","author":[{"given":"Ai","family":"Tsuiki","sequence":"first","affiliation":[{"name":"Division of Scientific Resources NCEZID CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Henning","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundaram","family":"Vishwanathan","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuong","family":"Dinh","sequence":"additional","affiliation":[{"name":"Total Solutions Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Adams","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Bachman","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pathology Yerkes National Primate Research Center Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Scientific Resources NCEZID CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hendry","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"McNicholl","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Kersh","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention NCHHSTP CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2012.01.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193748"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-3-35"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307687200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01419-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3248"},{"key":"e_1_2_6_8_1","unstructured":"CDC.HIV Surveillance Report \u2013 Diagnoses of HIV infection and AIDS in the United States and Dependent Areas Vol22.2010[cited 2012 July]; Available from:http:\/\/www.cdc.gov\/hiv\/surveillance\/resources\/reports\/2010report\/pdf\/2010_HIV_Surveillance_Report_vol_22.pdf#Page=1."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.05.002"},{"volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011","author":"Council NR","key":"e_1_2_6_10_1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70056-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S8927"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2011.07.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0910fje"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462971919994"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03017.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2009.038372"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200003000-00010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.535"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043951"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01085.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07831"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000210608.70762.c3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7283.410"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/655968"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00056-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.9217-9227.2005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11398"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis465"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92480-4"},{"key":"e_1_2_6_32_1","first-page":"707","article-title":"Effects of FTY720 in MRL\u2010lpr\/lpr mice: therapeutic potential in systemic lupus erythematosus","volume":"29","author":"Okazaki H","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01073-09"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240142"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0703-847"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(99)80034-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.454"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009310"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)00202-9"},{"key":"e_1_2_6_40_1","unstructured":"UNAIDS.Global Report \u2013 UNAIDS Report on the Global AIDS Epidemic.2010[cited 2012 April]; Available from:http:\/\/www.unaids.org\/globalreport\/Global_report.htm."},{"key":"e_1_2_6_41_1","first-page":"CD003255","article-title":"Condom effectiveness in reducing heterosexual HIV transmission","author":"Weller S","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_42_1","unstructured":"WHO.HIV\/AIDS \u2013 Fact sheet N\u00b0360.2012[cited 2012; Available from:http:\/\/www.who.int\/mediacentre\/factsheets\/fs360\/en\/index.html."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034830"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1353"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T04:58:43Z","timestamp":1698641923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,12]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jmp.12033"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12033","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"type":"print","value":"0047-2565"},{"type":"electronic","value":"1600-0684"}],"subject":[],"published":{"date-parts":[[2013,1,12]]}}}