{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:08:42Z","timestamp":1773644922251,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonhuman primates (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>s) are an important model organism for studies of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> pathogenesis and preclinical evaluation of anti\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> therapies. The successful translation of <jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>\u2010derived data to clinically relevant anti\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> studies will require better understanding of the viral strains and <jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> species used and their responses to existing antiretroviral therapies (<jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five pigtailed macaques (<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>acaca nemestrina<\/jats:italic>) were productively infected with the SIV\/HIV chimeric virus SHIV\u20101157 ipd3N4 following intravenous challenge. After 8 or 27\u00a0weeks, <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PMPA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FTC<\/jats:styled-content>, raltegravir) was initiated. Viral load, T\u2010cell counts, and production of <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content>\u2010specific antibodies were monitored throughout the course of infection and <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ART led to a rapid and sustained decrease in plasma viral load. Suppression of plasma viremia by <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> was independent of the timing of initiation during chronic infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present a new <jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> model of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection on antiretroviral therapy, which should prove applicable to multiple clinically relevant anti\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12060","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T07:42:20Z","timestamp":1378971740000},"page":"237-246","source":"Crossref","is-referenced-by-count":17,"title":["Robust suppression of env\u2010<scp>SHIV<\/scp> viremia in <i><scp>M<\/scp>acaca nemestrina<\/i> by 3\u2010drug <scp>ART<\/scp> is independent of timing of initiation during chronic infection"],"prefix":"10.1111","volume":"42","author":[{"given":"Christopher W.","family":"Peterson","sequence":"first","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Younan","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S.","family":"Polacino","sequence":"additional","affiliation":[{"name":"Washington National Primate Research Center University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Maurice","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah W.","family":"Miller","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Prlic","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Global Health University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith R.","family":"Jerome","sequence":"additional","affiliation":[{"name":"Washington National Primate Research Center University of Washington Seattle WA USA"},{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Laboratory Medicine University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Woolfrey","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Division of Pediatric Hematology\u2010Oncology Children\u2019s Hospital and Regional Medical Center Seattle WA USA"},{"name":"Department of Pediatrics University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiu\u2010Lok","family":"Hu","sequence":"additional","affiliation":[{"name":"Washington National Primate Research Center University of Washington Seattle WA USA"},{"name":"Department of Pharmaceutics University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Peter","family":"Kiem","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"},{"name":"Department of Medicine University of Washington School of Medicine Seattle WA USA"},{"name":"Department of Pathology University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01301-07"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.7.9.1419"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40767"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-9-32"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2010.00451.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-88"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01963-12"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-78"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709511105"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02499-06"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2000.290307.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280590922829"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0102-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328358e484"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-010-0005-2"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2911"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2011.00488.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-65"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1531159"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7213"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-94"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318266be53"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01701-10"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082831"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.07.012"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000214822.33905.87"},{"key":"e_1_2_5_28_1","first-page":"903","article-title":"Probiotic\/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV\u2010infected macaques","volume":"123","author":"Klatt NR","year":"2013","journal-title":"J Clin Invest"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06033-11"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022010"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110187"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-21"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01691-07"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-351155"},{"key":"e_1_2_5_35_1","first-page":"251","article-title":"Comparison of HIV\u2010specific CD8 T\u2010cell responses among uninfected individuals exposed to HIV parenterally and mucosally","volume":"19","author":"Makedonas G","year":"2005","journal-title":"AIDS"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201360"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-269"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.09-0588"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2000.290304.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535520"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr478"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2007.00243.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3134-3146.1999"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-9"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4938-4949.2003"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002774"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-S1-S7"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00558-06"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-1-9"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007693"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032827"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-160077"},{"key":"e_1_2_5_53_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/jvi.71.1.284-290.1997","article-title":"Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival","volume":"71","author":"Watson A","year":"1997","journal-title":"J Virol"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.100"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.03.016"},{"key":"e_1_2_5_56_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/135965350400900115","article-title":"Susceptibility of HIV\u20102, SIV and SHIV to various anti\u2010HIV\u20101 compounds: implications for treatment and postexposure prophylaxis","volume":"9","author":"Witvrouw M","year":"2004","journal-title":"Antivir Ther"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02497-12"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12060","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:43:05Z","timestamp":1696272185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,12]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/jmp.12060"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12060","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,12]]}}}