{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:41:25Z","timestamp":1696311685616},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CDC","award":["Y1-A1-0681-02"],"award-info":[{"award-number":["Y1-A1-0681-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010acting, hormonal contraception may increase <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> risk. Copper intrauterine devices (<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>s) could serve as non\u2010hormonal alternatives. We pilot a pigtail macaque model for evaluating <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> susceptibility factors during copper <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Frameless and flexible GyneFix<jats:sup>\u00ae<\/jats:sup> copper <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>s were surgically implanted into three <jats:styled-content style=\"fixed-case\">SHIV<jats:sub>SF<\/jats:sub><\/jats:styled-content><jats:sub>162p3<\/jats:sub>\u2010positive macaques via hysterotomy and monitored for up to 4\u00a0months. Four macaques served as non\u2010<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All animals retained the devices without complications. No consistent change in vaginal viral <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> or inflammatory cytokines was seen. Two animals had altered menstrual cycles and experienced marked thinning of vaginal epithelium after <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> insertion. Histological examination of uterine tissue at necropsy revealed endometrial ulceration and lymphocytic inflammation with glandular loss at sites of direct <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> contact.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the need for insertion surgery could limit its usefulness, this model will allow studies on copper <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content> shedding, disease progression, and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> susceptibility factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12096","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T09:18:56Z","timestamp":1388135936000},"page":"349-359","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of pigtail macaques as a model for the effects of copper intrauterine devices on <scp>HIV<\/scp> infection"],"prefix":"10.1111","volume":"43","author":[{"given":"Robyn M.","family":"Engel","sequence":"first","affiliation":[{"name":"Animal Resources Branch Division of Scientific Resources National Center for Emerging and Zoonotic Infectious Diseases CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Morris","sequence":"additional","affiliation":[{"name":"Total Solutions Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Henning","sequence":"additional","affiliation":[{"name":"Laboratory Branch Division of HIV\/AIDS Prevention National Center for HIV\/AIDS, Viral Hepatitis, Sexually Transmitted Disease, and Tuberculosis Prevention CDC Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana M.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Infectious Diseases Pathology Branch Division of High 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