{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:59:02Z","timestamp":1773100742129,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drugs commonly used to sedate non\u2010human primates for physiological sample collection can affect the metabolic system and alter rates of glucose metabolism. This study was designed to compare the physiological and metabolic effects of ketamine\/diazepam, telazol, and ketamine\/dexmedetomidine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven female rhesus monkeys underwent intravenous glucose tolerance testing under each of three anesthesia conditions. Blood glucose, insulin, physiological parameters, and sedation characteristics were measured and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Glucose and insulin values were both significantly impacted by ketamine\/dexmedetomidine sedation while remaining consistent during ketamine and telazol sedation. Heart rate was also significantly lowered during ketamine\/dexmedetomidine anesthesia. Though, ketamine\/dexmedetomidine resulted in a longer time between induction of anesthesia and need for a supplemental dose of anesthesia drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Telazol and ketamine have minimal cardiorespiratory and metabolic effects compared to ketamine\/dexmedetomidine. Although practicably interchangeable, telazol appears to be the most efficient for intravenous glucose tolerance testings with non\u2010human primates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12104","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T05:52:49Z","timestamp":1391752369000},"page":"162-168","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of anesthesia protocols for intravenous glucose tolerance testing in rhesus monkeys"],"prefix":"10.1111","volume":"43","author":[{"given":"Kelli L.","family":"Vaughan","sequence":"first","affiliation":[{"name":"Translational Gerontology Branch Intramural Research Program National Institute on Aging, NIH Dickerson MD USA"},{"name":"SoBran, Inc. 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Burtonsville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Herbert","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Disease NIH Animal Center Dickerson MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Mattison","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch Intramural Research Program National Institute on Aging, NIH Dickerson MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr022"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00619.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011300"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00087-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/014107689408701015","article-title":"Glucose tolerance and ageing","volume":"87","author":"Stout RW","year":"1994","journal-title":"J R Soc Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523001012"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.10.032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmp.12039"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.1350030118"},{"key":"e_1_2_5_11_1","first-page":"32","article-title":"Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats","volume":"42","author":"Sun FJ","year":"2003","journal-title":"Contemp Top Lab Anim"},{"key":"e_1_2_5_12_1","first-page":"57","article-title":"Comparison of the effects of ketamine, ketamine\u2010medetomidine, and ketamine\u2010midazolam on physiological parameters and anesthesia\u2010induced stress in rhesus (macaca mulatta) and cynomologus (macaca fascicularis) macaques","volume":"49","author":"Lee VK","year":"2010","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00699.x"},{"key":"e_1_2_5_14_1","first-page":"278","article-title":"Neurohormonal and metabolic effects of medetomidine compared to xylazine in healthy cats","volume":"72","author":"Kanda T","year":"2008","journal-title":"Can J Vet Res"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2987.2004.00147.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114621109"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:35:37Z","timestamp":1696221337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jmp.12104"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12104","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"value":"0047-2565","type":"print"},{"value":"1600-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,7]]}}}