{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:56:06Z","timestamp":1740124566254,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["Y1\u2010A1\u20100681\u201002"],"award-info":[{"award-number":["Y1\u2010A1\u20100681\u201002"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rectal STI coinfection models enhance the understanding of rectal HIV transmission risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Rhesus macaques (n=9) were exposed to one of three rectal <jats:italic>Chlamydia trachomatis<\/jats:italic> (CT) challenges: <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>trachomatis<\/jats:italic> L<jats:sub>2<\/jats:sub> (CT\u2010L<jats:sub>2<\/jats:sub>); <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>trachomatis<\/jats:italic> serovar E (CT\u2010E), followed by CT\u2010L<jats:sub>2<\/jats:sub>; or CT\u2010E, treatment\/clearance, then CT\u2010L<jats:sub>2<\/jats:sub>. Infections were monitored by PCR. Weekly blood and rectal secretion\/lavage samples were collected for cytokine analyzes and\/or epithelial sloughing, occult, and overt blood determinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chlamydial infections were successfully established in each animal, with varying degrees of persistence. Mucosal IL\u20101beta was upregulated in animals consecutively infected with CT\u2010E then CT\u2010L<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic>=.05). Epithelial sloughing was also significantly increased post\u2010infection in this group (<jats:italic>P<\/jats:italic>=.0003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates successful rectal infection of rhesus macaques with CT\u2010E and CT\u2010L<jats:sub>2<\/jats:sub> and describes measures of assessing rectal inflammation and pathology. Different infection strategies yield varying inflammatory and pathologic outcomes, providing well\u2010described models for future SIV\/SHIV susceptibility studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12272","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T12:16:39Z","timestamp":1494418599000},"page":"218-227","source":"Crossref","is-referenced-by-count":5,"title":["Development of a rectal sexually transmitted infection (STI) Model in Rhesus macaques using <i>Chlamydia trachomatis<\/i> serovars E and L<sub>2<\/sub>"],"prefix":"10.1111","volume":"46","author":[{"given":"Tara R.","family":"Henning","sequence":"first","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Morris","sequence":"additional","affiliation":[{"name":"Total Solutions  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanon","family":"Ellis","sequence":"additional","affiliation":[{"name":"Total Solutions  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Kelley","sequence":"additional","affiliation":[{"name":"McNeal Professional Services  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Ritter","sequence":"additional","affiliation":[{"name":"Division of High Consequence Pathogens and Pathology Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of High Consequence Pathogens and Pathology Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Nachamkin","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeyoung","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"McNicholl","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Papp","sequence":"additional","affiliation":[{"name":"Division of STD Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3819-0324","authenticated-orcid":false,"given":"Ellen N.","family":"Kersh","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"unstructured":"Division of HIV\/AIDS Prevention: HIV\/AIDS Topics: HIV Among Gay and Bisexual Men. 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