{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:24:14Z","timestamp":1758925454500,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI03461"],"award-info":[{"award-number":["U19AI03461"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intravaginal rings (<jats:styled-content style=\"fixed-case\">IVR<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> prevention will likely be used by women on depot medroxyprogesterone acetate (<jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>) hormonal contraception. We used pigtailed macaques to evaluate the effects of <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> on tenofovir disoproxil fumarate (<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">IVR<\/jats:styled-content> pharmacokinetics and viral shedding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mucosal tenofovir (<jats:styled-content style=\"fixed-case\">TFV<\/jats:styled-content>) levels were compared in <jats:styled-content style=\"fixed-case\">SHIV<jats:sub>SF<\/jats:sub><\/jats:styled-content><jats:sub>162p3<\/jats:sub>\u2010negative <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>\u2010treated (n=4) and normally cycling (n=6) macaques receiving <jats:styled-content style=\"fixed-case\">TDF IVR<\/jats:styled-content>s. Plasma viremia and vaginal shedding were determined in groups of <jats:styled-content style=\"fixed-case\">SHIV<jats:sub>SF<\/jats:sub><\/jats:styled-content><jats:sub>162p3<\/jats:sub>\u2010positive <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>\u2010treated (n=6) and normally cycling (n=5) macaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Similar median vaginal fluid <jats:styled-content style=\"fixed-case\">TFV<\/jats:styled-content> concentrations were observed in the <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>\u2010treated and cycling macaques over 4\u00a0weeks (1.2\u00d710<jats:sup>5<\/jats:sup> and 1.1.\u00d710<jats:sup>5<\/jats:sup>\u00a0ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively). Median plasma viremia and vaginal shedding <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of the <jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content>\u2010treated (2.73\u00d710<jats:sup>7<\/jats:sup> and 8.15\u00d710<jats:sup>4<\/jats:sup> copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively) and cycling macaques (3.98\u00d710<jats:sup>7<\/jats:sup> and 1.47\u00d710<jats:sup>3<\/jats:sup> copies\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively) were statistically similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DMPA<\/jats:styled-content> does not affect <jats:styled-content style=\"fixed-case\">TDF IVR<\/jats:styled-content> pharmacokinetics or <jats:styled-content style=\"fixed-case\">SHIV<\/jats:styled-content> shedding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12299","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T05:25:29Z","timestamp":1501133129000},"page":"129-136","source":"Crossref","is-referenced-by-count":2,"title":["Repeated administration of high\u2010dose depot medroxyprogesterone acetate does not alter <scp>SHIV<sub>SF<\/sub><\/scp><sub>162p3<\/sub> viral kinetics and tenofovir pharmacokinetics when delivered via intravaginal rings"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-6532","authenticated-orcid":false,"given":"Priya","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jining","family":"Zhang","sequence":"additional","affiliation":[{"name":"Total Solutions Inc.  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuong T.","family":"Dinh","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S.","family":"Teller","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Northwestern University  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet M.","family":"McNicholl","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick F.","family":"Kiser","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Northwestern University  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy C.","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Microbiology\u2010Immunology Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UNAIDS report on the global AIDS epidemic 2013.http:\/\/files.unaids.org\/en\/media\/unaids\/contentassets\/documents\/epidemiology\/2013\/gr2013\/UNAIDS_Global_Report_2013_en.pdf"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402269"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202614"},{"key":"e_1_2_6_6_1","unstructured":"ReesH Delany\u2010MoretlweAS LombardC et\u00a0al.FACTS 001 phase III trial of pericoital tenofovir 1% gel for HIV prevention in women. In: Conference on Retroviruses and Opportunistic Infections 2015."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193748"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000298338.58511.d1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.04.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506110"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2476"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000402"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157061"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00082-16"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02336-13"},{"key":"e_1_2_6_16_1","first-page":"27","article-title":"Microbicide dosage forms","volume":"383","author":"Rohan LC","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007385"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602046"},{"key":"e_1_2_6_19_1","unstructured":"BrownE Palanee\u2010PhilipsT MarzinkeM et\u00a0al.Residual dapivirine ring levels indicate higher adherence to vaginal ring is associated with HIV\u20101 protection.AIDS 2016."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000194602.01058.e1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.05.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.01.021"},{"key":"e_1_2_6_23_1","unstructured":"United Nations.World Contraceptive Use 2011.2011.http:\/\/www.un.org\/esa\/population\/publications\/contraceptive2011\/wallchart_front.pdf"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311355110"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04701-14"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000187"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmp.12119"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05842-11"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05721-11"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.01.040"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/507306"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.1.18617"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421303"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000493"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000340"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/890160"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.772579"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","unstructured":"BalkusJ Palanee\u2010PhillipsT SivaS et\u00a0al.Dapivirine ring use does not diminish the effectiveness of hormonal contraception. In: Conference on Retroviruses and Opportunistic Infections 2017.","DOI":"10.1097\/QAI.0000000000001455"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2012.0271"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12415"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000391"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70247-X"},{"key":"e_1_2_6_43_1","unstructured":"PatelR BaetenJ HeffronR et\u00a0al.Hormonal contraception does not affect ART effectiveness or genital HIV shedding. In: Conference on Retroviruses and Opportunistic Infections 2017."},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000294"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12299","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T06:13:15Z","timestamp":1694671995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jmp.12299"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12299","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"type":"print","value":"0047-2565"},{"type":"electronic","value":"1600-0684"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}