{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:56:09Z","timestamp":1740124569775,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In various types of pulmonary research, pulmonary function testing (<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>) is performed to quantify the severity of lung disease. Induction of apnea and positive pressure ventilation are required for accurate<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>measurements in non\u2010cooperative subjects. We compared two methods of apnea induction in infant olive baboons (<jats:italic>Papio anubis<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pulmonary function testing results were compared during apnea induced by hyperventilation (<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub>washout) vs. intravenous propofol (1 dose 10\u00a0mg\/kg).<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>was evaluated using a hot\u2010wire pneumotachometer incorporated within an Avea ventilator in nine 1\u2010month\u2010old baboons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Propofol induced apnea faster and more reliably. In both groups,<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>values passed the statistical equivalence test and were not significantly different (Student's<jats:italic>t<\/jats:italic>\u2010test). There was a trend toward less data variability after propofol administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous propofol was non\u2010inferior to<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub>washout for apnea induction in infant olive baboons. Propofol induced apnea faster and more reliably and yielded less variable<jats:styled-content style=\"fixed-case\">PFT<\/jats:styled-content>results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12306","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T10:14:40Z","timestamp":1507803280000},"page":"46-50","source":"Crossref","is-referenced-by-count":0,"title":["Apnea induction for invasive lung function testing in infant olive baboons: Comparison of intravenous propofol versus hyperventilation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-7006","authenticated-orcid":false,"given":"Vadim A.","family":"Ivanov","sequence":"first","affiliation":[{"name":"Oklahoma University Health Sciences Center Oklahoma City OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman F.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Oklahoma City VA Health Care System Oklahoma City OK 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