{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:31Z","timestamp":1787015491157,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The aim of the study was to evaluate the genetic predisposition of congenital cataract in a colony of captive\u2010bred vervet monkeys.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Four congenital cataract genes: glucosaminyl (N\u2010acetyl) transferase 2 (\n \n GCNT<\/jats:styled-content>\n 2\n <\/jats:italic>\n ), heat shock transcription factor 4 (\n \n HSF<\/jats:styled-content>\n 4\n <\/jats:italic>\n ), crystallin alpha A (\n \n CRYAA<\/jats:styled-content>\n <\/jats:italic>\n ) and lens intrinsic membrane protein\u20102 (\n \n LIM<\/jats:styled-content>\n 2\n <\/jats:italic>\n ) were screened, sequenced and analysed for possible genetic variants in 36 monkeys. Gene expression was also evaluated in these genes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifteen sequence variants were identified in the coding regions of three genes (\n \n GCNT<\/jats:styled-content>\n 2\n <\/jats:italic>\n ,\n \n HSF<\/jats:styled-content>\n 4\n <\/jats:italic>\n and\n \n CRYAA<\/jats:styled-content>\n <\/jats:italic>\n ). Of these variations, only three were missense mutations (M258V, V16I and S24N) and identified in the\n \n GCNT<\/jats:styled-content>\n 2\n <\/jats:italic>\n transcripts A, B and C, respectively, which resulted in a downregulated gene expression.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Although the three missense mutations in\n \n GCNT<\/jats:styled-content>\n 2\n <\/jats:italic>\n have a benign effect, a possibility exists that the candidate genes (\n \n GCNT<\/jats:styled-content>\n 2\n <\/jats:italic>\n ,\n \n HSF<\/jats:styled-content>\n 4\n <\/jats:italic>\n and\n \n CRYAA<\/jats:styled-content>\n <\/jats:italic>\n ) might harbour mutations that are responsible for total congenital cataract.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jmp.12332","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T17:05:50Z","timestamp":1517245550000},"page":"93-100","source":"Crossref","is-referenced-by-count":8,"title":["Autosomal recessive congenital cataract in captive\u2010bred vervet monkeys (\n Chlorocebus aethiops<\/i>\n )"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-6018","authenticated-orcid":false,"given":"Zandisiwe E.","family":"Magwebu","sequence":"first","affiliation":[{"name":"Primate Unit and Delft Animal Centre (PUDAC) South African Medical Research Council (SAMRC) Tygerberg Cape Town South Africa"},{"name":"Medical Bioscience Department University of the Western Cape Belville South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Abdul\u2010Rasool","sequence":"additional","affiliation":[{"name":"Medical Bioscience Department University of the Western Cape Belville South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen V.","family":"Seier","sequence":"additional","affiliation":[{"name":"Primate Unit and Delft Animal Centre (PUDAC) South African Medical Research Council (SAMRC) Tygerberg Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chesa G.","family":"Chauke","sequence":"additional","affiliation":[{"name":"Primate Unit and Delft Animal Centre (PUDAC) South African Medical Research Council (SAMRC) Tygerberg Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2005.00102.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.24.69"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0684.1985.tb00181.x","article-title":"Congenital cataract in a Free\u2010Ranging Rhesus Monkey","volume":"14","author":"Kessler MJ","year":"1985","journal-title":"J Med 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