{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:56:13Z","timestamp":1740124573322,"version":"3.37.3"},"reference-count":86,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010178","name":"Indiana University Bloomington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010178","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009702","name":"Animal Behavior Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011084","name":"Sigma Xi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006838","name":"American Society of Primatologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We present 3 likely cases of testicular dysgenesis syndrome (TDS) within a community of chimpanzees (<jats:italic>Pan troglodytes schweinfurthii<\/jats:italic>). We tested whether genetic drift may be the culprit, as a genetic cause has been suspected to account for TDS among other wildlife.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We successfully sequenced a 367\u2010bp segment spanning the first hypervariable region within the D\u2010loop of the mitochondrial genome for 78 DNA samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 24 polymorphic sequence sites consisting of 7 singletons and 17 parsimony informative sites. This sample contained 9 haplotypes with a diversity index of 0.78 (SD\u00a0=\u00a00.03). All tests against the null hypothesis of neutral polymorphisms were non\u2010significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.10). The mismatch distribution of pairwise differences does not fit a Poisson's curve (raggedness index\u00a0=\u00a00.166; SSD\u00a0=\u00a00.12; <jats:italic>P<\/jats:italic>\u00a0=\u00a01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thus, we found no significant signs of genetic isolation, population expansion, or genetic bottleneck. Alternative causes of TDS and how they might pertain to this population are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12352","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T09:30:19Z","timestamp":1527240619000},"page":"257-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is genetic drift to blame for testicular dysgenesis syndrome in Semliki chimpanzees (<i>Pan troglodytes schweinfurthii<\/i>)?"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-3394","authenticated-orcid":false,"given":"Alicia M.","family":"Rich","sequence":"first","affiliation":[{"name":"Department of Anthropology Boston University  Boston MA USA"},{"name":"Department of Anthropology Indiana University  Bloomington IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Department of Anthropology Indiana University  Bloomington IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Deimel","sequence":"additional","affiliation":[{"name":"Department of Anthropology Indiana University  Bloomington IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott K.","family":"Breeden","sequence":"additional","affiliation":[{"name":"Marian University College of Osteopathic Medicine  Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederika","family":"Kaestle","sequence":"additional","affiliation":[{"name":"Department of Anthropology Indiana University  Bloomington IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Anthropology Indiana University  Bloomington IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1038\/432048a"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1111\/j.1464-410X.2004.04703.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1093\/humupd\/dmx022"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1093\/humrep\/16.5.972"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1530\/REP-06-0272"},{"key":"e_1_2_7_7_1","first-page":"959","volume-title":"Pathologic Basis of Disease. Ninth","author":"Epstein J","year":"2015"},{"unstructured":"Schoni\u2010AffolterF Dubuis\u2010GriederC StrauchE.Online course in embryology for medicine students.http:\/\/www.embryology.ch\/indexen.html. Published 2008. Accessed June 6 2017.","key":"e_1_2_7_8_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1177\/1756287209105266"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1210\/er.18.2.259"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.3389\/fendo.2013.00032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0094-0143(21)01021-1","article-title":"The undescended testis \u2013 theory and management","volume":"22","author":"Rozanski T","year":"1995","journal-title":"Urol Clin North Am"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1016\/j.jpurol.2010.11.001"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1159\/000049960"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1016\/S0022-5347(17)66554-6"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1111\/j.1464-410X.1960.tb00031.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1596\/978-1-4648-0346-8_ch9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1016\/j.pop.2010.04.009"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1016\/S0015-0282(16)53467-0"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1002\/ar.1090570204"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1016\/j.livsci.2015.06.022"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.1016\/j.jevs.2016.06.008"},{"key":"e_1_2_7_23_1","first-page":"485","article-title":"Genetic introgression within the Florida panther Felis concolor coryi","volume":"6","author":"O'Brien SJ","year":"1990","journal-title":"Natl Geogr Res"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.1007\/BF02189694"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.7589\/0090-3558-32.4.661"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_1","DOI":"10.1002\/ajp.1350260407"},{"doi-asserted-by":"publisher","key":"e_1_2_7_27_1","DOI":"10.7589\/0090-3558-38.4.693"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1016\/B978-0-12-381366-4.00010-9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_29_1","DOI":"10.1002\/ajp.1350030518"},{"doi-asserted-by":"publisher","key":"e_1_2_7_30_1","DOI":"10.1007\/BF02381860"},{"doi-asserted-by":"publisher","key":"e_1_2_7_31_1","DOI":"10.1095\/biolreprod44.3.448"},{"volume-title":"The Chimpanzees of Gombe: Patterns of Behavior\/Jane Goodall","year":"1986","author":"Goodall J","key":"e_1_2_7_32_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_33_1","DOI":"10.1002\/ajpa.1330630102"},{"key":"e_1_2_7_34_1","first-page":"1381.e1","volume-title":"Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"McGowan CC","year":"2014"},{"doi-asserted-by":"publisher","key":"e_1_2_7_35_1","DOI":"10.1002\/ajp.22442"},{"doi-asserted-by":"publisher","key":"e_1_2_7_36_1","DOI":"10.1289\/ehp.11748"},{"doi-asserted-by":"publisher","key":"e_1_2_7_37_1","DOI":"10.1677\/joe.0.1580327"},{"doi-asserted-by":"publisher","key":"e_1_2_7_38_1","DOI":"10.1001\/jamainternmed.2016.5766"},{"doi-asserted-by":"publisher","key":"e_1_2_7_39_1","DOI":"10.1007\/1-59745-107-X"},{"doi-asserted-by":"publisher","key":"e_1_2_7_40_1","DOI":"10.1093\/humupd\/7.3.248"},{"doi-asserted-by":"publisher","key":"e_1_2_7_41_1","DOI":"10.1289\/ehp.9351"},{"doi-asserted-by":"publisher","key":"e_1_2_7_42_1","DOI":"10.1677\/JME-08-0132"},{"doi-asserted-by":"publisher","key":"e_1_2_7_43_1","DOI":"10.1111\/jmp.12129"},{"doi-asserted-by":"publisher","key":"e_1_2_7_44_1","DOI":"10.1016\/j.scitotenv.2017.04.113"},{"doi-asserted-by":"publisher","key":"e_1_2_7_45_1","DOI":"10.1093\/oxfordjournals.jhered.a103951"},{"doi-asserted-by":"publisher","key":"e_1_2_7_46_1","DOI":"10.1016\/j.anireprosci.2008.07.004"},{"doi-asserted-by":"publisher","key":"e_1_2_7_47_1","DOI":"10.1002\/zoo.1430050212"},{"key":"e_1_2_7_48_1","first-page":"51","article-title":"Speciation and the founder principle","volume":"3","author":"Carson H","year":"1971","journal-title":"Stadler Genet Symp"},{"doi-asserted-by":"publisher","key":"e_1_2_7_49_1","DOI":"10.1016\/0040-5809(77)90045-4"},{"doi-asserted-by":"publisher","key":"e_1_2_7_50_1","DOI":"10.1016\/0960-9822(93)90197-V"},{"doi-asserted-by":"publisher","key":"e_1_2_7_51_1","DOI":"10.1111\/j.1469-1795.2008.00174.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_52_1","DOI":"10.1017\/S1367943001001251"},{"unstructured":"AkwetairehoS PlumptreAJ NangendoG.Assessment of corridors in the Murchison\u2010Semliki Landscape. February2010. Unpublished Report to UNDP\/GEF project UG0031.01.","key":"e_1_2_7_53_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_54_1","DOI":"10.1093\/oxfordjournals.molbev.a025841"},{"doi-asserted-by":"publisher","key":"e_1_2_7_55_1","DOI":"10.1896\/052.026.0105"},{"doi-asserted-by":"publisher","key":"e_1_2_7_56_1","DOI":"10.1016\/j.jhevol.2013.12.005"},{"doi-asserted-by":"publisher","key":"e_1_2_7_57_1","DOI":"10.1111\/j.1365-294X.2008.03675.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_58_1","DOI":"10.1007\/s10329-012-0329-z"},{"key":"e_1_2_7_59_1","first-page":"161","article-title":"Feeding ecology of savanna chimpanzees (Pan troglodytes verus) at Fongoli, Senegal","author":"Pruetz JD","year":"2006","journal-title":"The Feeding Ecology of Great Apes and other Primates"},{"doi-asserted-by":"publisher","key":"e_1_2_7_60_1","DOI":"10.1007\/s10329-014-0434-2"},{"doi-asserted-by":"publisher","key":"e_1_2_7_61_1","DOI":"10.1007\/s10764-007-9210-0"},{"doi-asserted-by":"publisher","key":"e_1_2_7_62_1","DOI":"10.1017\/CBO9780511606397.005"},{"doi-asserted-by":"publisher","key":"e_1_2_7_63_1","DOI":"10.1046\/j.1365-294x.1998.00374.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_64_1","DOI":"10.1111\/j.1365-294X.2007.03089.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_65_1","DOI":"10.1111\/j.1365-294X.2005.02577.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_66_1","DOI":"10.1111\/j.1365-294X.2004.02207.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_67_1","DOI":"10.1111\/j.1755-0998.2008.02387.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_68_1","DOI":"10.1046\/j.0962-1083.2001.01308.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_69_1","DOI":"10.1023\/A:1011847528045"},{"key":"e_1_2_7_70_1","first-page":"636","article-title":"A rapid and quantitative DNA sex test: fluorescence\u2010based PCR analysis of X\u2010Y homologous gene amelogenin","volume":"15","author":"Sullivan KM","year":"1993","journal-title":"Biotechniques"},{"doi-asserted-by":"publisher","key":"e_1_2_7_71_1","DOI":"10.1111\/j.1755-0998.2010.02847.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_72_1","DOI":"10.1093\/bioinformatics\/btp187"},{"volume-title":"Genetics and Biogeography of East African Chimpanzees (Pan Troglodytes Schweinfurthii)\/by Tony Lawrence Goldberg","year":"1996","author":"Goldberg TL","key":"e_1_2_7_73_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_74_1","DOI":"10.1371\/journal.pone.0000973"},{"doi-asserted-by":"publisher","key":"e_1_2_7_75_1","DOI":"10.1093\/genetics\/133.3.693"},{"doi-asserted-by":"publisher","key":"e_1_2_7_76_1","DOI":"10.1111\/j.1365-294X.2005.02683.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_77_1","DOI":"10.1093\/oxfordjournals.molbev.a026036"},{"doi-asserted-by":"publisher","key":"e_1_2_7_78_1","DOI":"10.1111\/j.1365-294X.2007.03285.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_79_1","DOI":"10.1093\/genetics\/129.2.555"},{"unstructured":"WilsonM CossetteJ KoopsK et\u00a0al.The most unkindest cut: genital wounding by chimpanzees. In:2015.","key":"e_1_2_7_80_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_81_1","DOI":"10.1111\/j.1365-294X.2012.05635.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_82_1","DOI":"10.1007\/s10764-013-9702-z"},{"doi-asserted-by":"publisher","key":"e_1_2_7_83_1","DOI":"10.1111\/j.1365-294X.2010.04888.x"},{"unstructured":"Stockholm Convention UNEP.Acceptable purposes: DDT.http:\/\/chm.pops.int\/Implementation\/Exemptions\/AcceptablePurposesDDT\/tabid\/456\/Default.aspx. Accessed June 6 2017.","key":"e_1_2_7_84_1"},{"unstructured":"Stockholm Convention UNEP.DDT register \u2013 withdrawn notifications.http:\/\/chm.pops.int\/Implementation\/Exemptions\/AcceptablePurposesDDT\/DDTRegisterWithdrawnnotifications\/tabid\/2684\/Default.aspx. Accessed June 6 2017.","key":"e_1_2_7_85_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_86_1","DOI":"10.2164\/jandrol.05121"},{"volume-title":"Status of Grauer's Gorilla and Chimpanzees in Eastern Democratic Republic of Congo: Historical and Current Distribution and Abundance","year":"2015","author":"Plumptre AJ","key":"e_1_2_7_87_1"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:33:42Z","timestamp":1694986422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,25]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jmp.12352"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12352","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"type":"print","value":"0047-2565"},{"type":"electronic","value":"1600-0684"}],"subject":[],"published":{"date-parts":[[2018,5,25]]},"assertion":[{"value":"2018-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}