{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:20:50Z","timestamp":1759602050691,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U54 HD 055744"],"award-info":[{"award-number":["U54 HD 055744"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["P51OD011092"],"award-info":[{"award-number":["P51OD011092"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Macaques are outstanding animal models for the development of new contraceptives. In women, progestin\u2010only contraceptives often fail to block ovulation and are believed to act by altering cervix physiology. Herein, we assessed oviductal glycoprotein 1 (OVGP1) in the macaque cervix as a marker for progestogen action.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>Rhesus macaques were treated with estradiol (E<jats:sub>2<\/jats:sub>), E<jats:sub>2<\/jats:sub> plus progesterone (P), and E<jats:sub>2<\/jats:sub> plus levonorgestrel (LNG), a contraceptive progestin. Samples consisted of archived blocks of midcervix mucosa (epithelium and lamina propria) and fresh epithelial cells collected non\u2010invasively by cytobrush. <jats:styled-content style=\"fixed-case\">OVGP<\/jats:styled-content>1 was assayed by quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and localized by immunocytochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OVGP<\/jats:styled-content>1 transcript was maximal after E<jats:sub>2<\/jats:sub> and reduced after treatment with E<jats:sub>2<\/jats:sub>\u00a0+\u00a0P (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). LNG also reduced <jats:styled-content style=\"fixed-case\">OVGP<\/jats:styled-content>1 expression (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). <jats:styled-content style=\"fixed-case\">OVGP<\/jats:styled-content>1\u2010specific staining localized to epithelial cells, and transcript was quantifiable in cytobrush collected samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OVGP<\/jats:styled-content>1 expression in cytobrush samples of macaque cervix provides a non\u2010invasive indicator of contraceptive progestin action.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12357","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T08:21:33Z","timestamp":1530692493000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hormonal regulation of oviductal glycoprotein 1 (<scp>OVGP<\/scp>1; <scp>MUC<\/scp>9) in the rhesus macaque cervix"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-8292","authenticated-orcid":false,"given":"Ov Daniel","family":"Slayden","sequence":"first","affiliation":[{"name":"Division of Reproductive and Developmental Sciences Oregon National Primate Research Center  Beaverton OR USA"},{"name":"Department of Obstetrics and Gynecology Oregon Health and Science University  Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis Kathryn E.","family":"Friason","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences Oregon National Primate Research Center  Beaverton OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kise Rosen","family":"Bond","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences Oregon National Primate Research Center  Beaverton OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily Cathleen","family":"Mishler","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences Oregon National Primate Research Center  Beaverton OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.04.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.04.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.06.006"},{"key":"e_1_2_7_5_1","first-page":"6","article-title":"Endometrial effects of progestogens","volume":"8","author":"Critchley H","year":"2003","journal-title":"Gynaecology 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