{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:56:17Z","timestamp":1740124577248,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital fused labia (<jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content>) is defined as a failure or significant delay in the opening of the juvenile sealed labia majora. This phenotype is known to be variably common in adult captive female marmosets but has never been investigated in detail before.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Here, we define, describe and quantify the variations in the degree of closure of the vulva in 122 captive marmosets (<jats:italic>Callithrix jacchus<\/jats:italic>) from 1.2 to 42\u00a0months old and include colony analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a negative correlation between the degree of labial fusion and animal age after prepubertal period (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content> females had higher number <jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content> relatives (4.3\u00a0\u00b1\u00a00.6 vs 2.4\u00a0\u00b1\u00a00.5 for non\u2010<jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00.05) and more external ancestors compared to non\u2010<jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results therefore suggest that <jats:styled-content style=\"fixed-case\">CFL<\/jats:styled-content> phenotype is most likely associated with epigenetic effects induced by the captive environment and colony management strategy of extensive crossing of family lines to promote heterozygosity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12387","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:19:00Z","timestamp":1540286340000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Developmental and family history\u2010based analysis of congenital fused labia phenotype in the captive common marmoset (<i>Callithrix jacchus<\/i>)"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-8636","authenticated-orcid":false,"given":"Edris","family":"Wedi","sequence":"first","affiliation":[{"name":"Laboratory of Biomedical Reproduction German Primate Centre  Goettingen Germany"},{"name":"Gastroenterology und GI Oncology University Medical Centre  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena Y.","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Reproduction German Primate Centre  Goettingen Germany"},{"name":"Division of Reproductive and Developmental Sciences Oregon National Primate Research Center Oregon Health and Science University  Beaverton Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Del Rio","family":"Do Valle","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Reproduction German Primate Centre  Goettingen Germany"},{"name":"Instituto de Ci\u00eancias da Sa\u00fade Health Sciences Institute Universidade Paulista Paulista University  S\u00e3o Paulo \u2013 SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Heistermann","sequence":"additional","affiliation":[{"name":"Endocrinology Laboratory German Primate Centre Leibniz Institute for Primate Research  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Wilhelm","family":"Michelmann","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Georg\u2010August\u2010University  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope L.","family":"Nayudu","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Reproduction German Primate Centre  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1034\/j.1600-0684.2002.t01-1-02002.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1111\/j.1600-0684.2011.00477.x"},{"key":"e_1_2_7_4_1","first-page":"539","article-title":"XY female marmoset (Callithrix jacchus)","volume":"53","author":"Sanchez\u2010Morgado JM","year":"2003","journal-title":"Comp Med"},{"issue":"3","key":"e_1_2_7_5_1","first-page":"86","article-title":"Occurrence of virilization signals in a female marmoset Leontopithecus chrysomelas (callitrichidae; primates) with 46, XX\/46, XY chimerism","volume":"60","author":"Goldschmidt B","year":"2005","journal-title":"Israel J Vet Med"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1292\/jvms.14-0378"},{"unstructured":"WediE.Untersuchung des CFL\u2010Ph\u00e4notyps (\u201ccongenital fused labia\u201d) in dem Neuweltaffen Common Marmoset (Callithrix jacchus) unter demographischen physiologischen und zytogenetischen Gesichtspunkten. In:Medizinische Fakultaet. Georg\u2010August\u2010Universitaet 2010.","key":"e_1_2_7_7_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1530\/jrf.0.0530155"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1023\/A:1005433722475"},{"unstructured":"Collections AoS History UoKMoN.ASC Newsletter: Association of Systematics Collections;1981.","key":"e_1_2_7_10_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1016\/j.theriogenology.2008.03.011"},{"unstructured":"TkachenkoO.In vitro oocyte maturation and embryo production in the common marmoset (Callithrix jacchus). In.Freie Universit\u00e4t Berlin;2012.","key":"e_1_2_7_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1071\/RD15321"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1016\/j.anireprosci.2015.03.014"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1111\/j.1440-1754.1993.tb00495.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1016\/S1083-3188(00)00064-4"},{"key":"e_1_2_7_17_1","first-page":"37","article-title":"Estrogen cream for labial adhesion in girls","volume":"59","author":"Goldman RD","year":"2013","journal-title":"Can Fam Physician"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1111\/j.1525-1470.2007.00493.x"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjmp.12387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.12387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T23:33:16Z","timestamp":1694734396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.12387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/jmp.12387"],"URL":"https:\/\/doi.org\/10.1111\/jmp.12387","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"type":"print","value":"0047-2565"},{"type":"electronic","value":"1600-0684"}],"subject":[],"published":{"date-parts":[[2018,10,23]]},"assertion":[{"value":"2018-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}