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The development of improved antiemetic pharmacotherapies has been impeded by a shortage of animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present studies characterized the responses of the squirrel monkey to pharmacologically diverse emetic drugs. Subjects were administered nicotine (0.032\u20100.56\u00a0mg\/kg), lithium chloride (150\u2010250\u00a0mg\/kg), arecoline (0.01\u20100.32\u00a0mg\/kg), or apomorphine (0.032\u20100.32\u00a0mg\/kg) and observed for emesis and prodromal hypersalivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nicotine rapidly produced emesis and hypersalivation. Lithium chloride produced emesis with a longer time course without dose\u2010dependent hypersalivation. Arecoline produced hypersalivation but not emesis. Apomorphine failed to produce emesis or hypersalivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The squirrel monkey is sensitive to drug\u2010induced emesis by a variety of pharmacological mechanisms and is well\u2010positioned to examine antiemetic efficacy and clinically important side effects of candidate antiemetic pharmacotherapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12411","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T11:41:16Z","timestamp":1554896476000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An assay of drug\u2010induced emesis in the squirrel monkey (<i>Saimiri sciureus<\/i>)"],"prefix":"10.1111","volume":"48","author":[{"given":"Lisa M.","family":"Wooldridge","sequence":"first","affiliation":[{"name":"Behavioral Biology Program McLean Hospital Belmont 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