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The animal began showing signs of neurological dysfunction post\u2010vaccination, which progressed and ultimately resulted in euthanasia. The underlying brain abnormality was revealed at necropsy and was subsequently investigated with gross and microscopic examination. This becomes the first reported case of an adverse event following administration of a live attenuated vaccine and suggests the possibility of an increased susceptibility risk of unwanted adverse outcome associated with vaccination in populations with pre\u2010existing conditions such as hydrocephalus.<\/jats:p>","DOI":"10.1111\/jmp.12414","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T06:33:58Z","timestamp":1554359638000},"page":"257-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adverse event following live attenuated chikungunya vaccine in a cynomolgus macaque with pre\u2010existing chronic hydrocephalus"],"prefix":"10.1111","volume":"48","author":[{"given":"Tiffany A.","family":"Peterson","sequence":"first","affiliation":[{"name":"Tulane National Primate Research Center Covington Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew 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