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This study compared the pharmacokinetics (PK) of the BCL6 BTB inhibitor (FX1) between mice and macaques, as well as evaluating its lymphoid suppressive effect in uninfected macaques with lymphoid hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eight uninfected adult Indian rhesus macaques (<jats:italic>Macaca mulatta<\/jats:italic>) were used in the study, four animals carrying lymphoid tissue hyperplasia. Plasma FX1 levels were measured by HPLC\u2010MS\/MS. Lymph node biopsies were used for H&amp;E and immunohistochemistry staining, as well as mononuclear cell isolation for flow cytometry analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inhibition of the BCL6 BTB domain with FX1 led to a reduction in the frequency of GC, Tfh CD4<jats:sup>+<\/jats:sup>, and Tfh precursor cells, as well as resolving lymphoid hyperplasia, in rhesus macaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>B\u2010cell lymphoma 6 inhibition may represent a novel strategy to reduce hyperplastic lymphoid B\u2010cell follicles and decrease Tfh cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12438","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T07:20:25Z","timestamp":1569914425000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["BCL6 BTB\u2010specific inhibition via FX1 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