{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:31:42Z","timestamp":1747186302392,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For the diagnosis and treatment of adult T\u2010cell leukemia\/lymphoma (ATLL) caused by human T\u2010lymphotropic virus type 1 (HTLV\u20101) are required therapeutic modalities urgently. Non\u2010human primate models for ATLL would provide a valuable information for clinical studies. We did a pilot study to establish an ATLL non\u2010human primate model using common marmosets (<jats:italic>Callithrix jacchus<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We inoculated HTLV\u20101\u2013producing MT\u20102 cells into 9\u2010month\u2010old marmosets, either intraperitoneally or intravenously. We next administrated MT\u20102 cells into 13\u2010month\u2010old marmosets under cyclosporine A (CsA) treatment to promote infection. HTLV\u20101 infection was determined by measuring HTLV\u20101 antibody titer in the common marmosets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HTLV\u20101 antibody titer increased in the intraperitoneally inoculated marmoset with or without CsA treatment, and it kept over five 5\u00a0years though proviral copy number (proviral load, PVL) remained low throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We obtained HTLV\u20101 asymptomatic carriers of common marmosets by inoculating MT\u20102 cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12454","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T03:25:02Z","timestamp":1578885902000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A pilot study to establish human T\u2010cell leukemia virus type 1 (HTLV\u20101) carrier model using common marmoset (<i>Callithrix jacchus<\/i>)"],"prefix":"10.1111","volume":"49","author":[{"given":"Lisa","family":"Hirose","sequence":"first","affiliation":[{"name":"Project Division of ALA Advanced Medical Research The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Hiramoto","sequence":"additional","affiliation":[{"name":"Project Division of ALA Advanced Medical Research The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamin","family":"Tian","sequence":"additional","affiliation":[{"name":"Project Division of ALA Advanced Medical Research The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kohara","sequence":"additional","affiliation":[{"name":"Project Division of ALA Advanced Medical Research The Institute 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