{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:39:24Z","timestamp":1774690764328,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is scarce information detailing clinical and physiological effects of reversible injectable protocols of chemical restraint on Neotropical primates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen captive Spix\u00b4s Owl monkeys (<jats:italic>Aotus vociferans<\/jats:italic>) were assessed in a double\u2010blind randomized crossover study using the following: ketamine\/xylazine [KX], ketamine\/midazolam [KM] and ketamine\/xylazine\/midazolam [KXM]. During immobilization, respiratory and pulse rates, rectal temperature, haemoglobin oxygen saturation and arterial blood pressure were recorded at 5\u2010minute intervals during a 20\u2010minute period; afterwards, antagonist drugs (yohimbine for xylazine and flumazenil for midazolam) were, respectively, administered. Quality and duration of induction, immobilization and recovery periods were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ketamine\/xylazine increased manipulation sensitivity and produced poor muscle relaxation. KM maintained all assessed parameters within physiological ranges. KXM produced depressant cardiorespiratory effects and hypotension. All protocols produced hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on its adequate anaesthetic depth and minimum effects on physiological parameters, KM is suitable for immobilizing <jats:italic>A\u00a0vociferans<\/jats:italic> and performing short\u2010term procedures lasting around 20\u00a0minutes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12462","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T09:49:25Z","timestamp":1581500965000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of three reversible injectable chemical restraint protocols in Spix\u00b4s Owl monkeys (<i>Aotus vociferans<\/i>) using ketamine, xylazine and midazolam"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-9917","authenticated-orcid":false,"given":"Jessy","family":"Alfonso","sequence":"first","affiliation":[{"name":"Laboratory of Animal Anatomy and Wildlife School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Lescano","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Anatomy and Wildlife School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miryam","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Anatomy and Wildlife School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine Small Animals Hospital Universidad Nacional Mayor de San Marcos Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"GozaloA.Clinical aspects of ketamine hydrochloride and xylazine association inAotussp. 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