{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:04:32Z","timestamp":1790625872144,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The successive reports of <jats:italic>Platynosomum illiciens<\/jats:italic> in Neotropical captive primates have increased interest in platynosomosis; however, its treatment is little known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Callithrix penicillata<\/jats:italic> (n\u00a0=\u00a010) naturally and chronically infected with <jats:italic>P.\u00a0illiciens<\/jats:italic> were treated with praziquantel (25\u00a0mg\/kg BW, three s.c. doses at 24\u00a0hours intervals), and coproparasitological tests performed over 67\u00a0days. The proportions of primates with a reduction in fecal egg counts (FEC) or negative results progressively increased after treatment, and at the last fecal tests, marmosets were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>Although all primates tolerated the initial days of study well, 40% (4\/10) of them died between the 8th and 16th days after the onset of treatment. Clinical signs and necropsies indicated the occurrence of hepatic involvement, biliary obstruction, and cholangitis. Marmosets with a higher previous FEC were more likely to die after treatment. Use of praziquantel should be considered carefully on a case\u2010by\u2010case basis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12503","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T18:16:53Z","timestamp":1605291413000},"page":"60-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Treatment of primate platynosomosis: A word of caution about the use of praziquantel in marmosets"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-6214","authenticated-orcid":false,"given":"Vitor Lu\u00eds Ten\u00f3rio","family":"Mati","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade Universidade Federal de Lavras Lavras Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-1348","authenticated-orcid":false,"given":"Hudson Alves","family":"Pinto","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-7210","authenticated-orcid":false,"given":"Alan Lane","family":"de Melo","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.12.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3926-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1645\/16-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-5866-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1590\/S1984-29612015014","article-title":"Evaluation of Kato\u2010Katz and spontaneous sedimentation methods for the diagnosis of platynosomiasis in Neotropical primates","volume":"24","author":"Mati VLT","year":"2015","journal-title":"Rev Bras Parasitol Vet"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-016-0520-8"},{"key":"e_1_2_8_8_1","first-page":"7","article-title":"Helminth parasites of Callithrix geoffroyi","volume":"43","author":"Melo AL","year":"2004","journal-title":"Lab Primate Newsl"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-008-0105-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10329-011-0281-3","article-title":"Occurrence of infection by Platynosomum illiciens (Braun, 1901) in captive Neotropical primates","volume":"53","author":"Silva KS","year":"2012","journal-title":"Primates"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-34.3.644"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1978.tb05583.x"},{"key":"e_1_2_8_13_1","first-page":"205511691558983","article-title":"Praziquantel treatment for Platynosomum species infection of a domestic cat on St Kitts, West Indies","volume":"1","author":"Shell L","year":"2015","journal-title":"JFMS Open Rep"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci5020035"},{"key":"e_1_2_8_15_1","first-page":"1271","article-title":"Platynosomum concinnum infection in cats","volume":"16","author":"Foley RH","year":"1994","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/9780470376805","volume-title":"Feline Clinical Parasitology","author":"Bowman DD","year":"2002"},{"key":"e_1_2_8_17_1","first-page":"1689","volume-title":"Textbook of Veterinary Internal Medicine","author":"Aguirre A","year":"2010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0001-706X(03)00031-7","article-title":"mebendazole and praziquantel. 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