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This study sought to determine its effectiveness as an appetite stimulant in macaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen macaques with idiopathic hyporexia, intractable to conventional management were treated with transdermal MTZ (0.5\u00a0mg\/kg) topically administered to aural pinnae once daily for 14\u00a0days. Qualitative food consumption was monitored daily for 6\u00a0months. Body weights were collected prior to treatment, every 2\u00a0weeks for the first 6\u00a0weeks, 10\u00a0weeks, and 6\u00a0months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transdermal MTZ significantly reduced the frequency of hyporexia during treatment and monthly for 6\u00a0months. No significant increase in weight noted until approximately 6\u00a0months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results from this study indicate that a short course of transdermal MTZ is an effective way to increase food consumption in macaques chronically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12512","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T23:13:27Z","timestamp":1612566807000},"page":"128-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques (<i>Macaca mulatta<\/i> and <i>Macaca fascicularis<\/i>)"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-729X","authenticated-orcid":false,"given":"Kriscelle A.","family":"Mendoza","sequence":"first","affiliation":[{"name":"Valley Biosystems West 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