{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:46:31Z","timestamp":1693313191217},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Capsaicin is used in several areas of non\u2010human primate research including allodynia and dermal blood flow (DBF). The capsaicin\u2010induced DBF increase was measured using laser Doppler imaging (LDI), but this response is known to diminish upon repeated topical applications. Refinement of the experimental procedures could improve the rigor and reproducibility of the DBF migraine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Optimal anatomical site in cynomolgus was determined, and conditions and experimental settings for DBF measurement using LDI were established. Then, two study design trial structures were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Medial thigh was the preferrable site, and an ethanol\u2010Tween 20 formulation of capsaicin was desirable. A 1\u2010week washout for contralateral side or 2\u2010week washout for ipsilateral side was necessary to eradicate capsaicin desensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With the established technicality in DBF measurements in cynomolgus macaques, the capsaicin\u2010induced DBF model may be utilized in translational medical research in developing migraine therapeutics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12544","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T04:36:43Z","timestamp":1632890203000},"page":"291-298","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of capsaicin\u2010induced dermal blood flow measurement by laser Doppler imaging in cynomolgus macaque"],"prefix":"10.1111","volume":"50","author":[{"given":"Sheung Pun","family":"Tsai","sequence":"first","affiliation":[{"name":"Valley Biosystems West 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