{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:05:00Z","timestamp":1790129100441,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AI123029"],"award-info":[{"award-number":["R01\u2010AI123029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Simian varicella virus (SVV) is a primate herpesvirus that causes a natural varicella\u2010like disease in Old World monkeys and may cause epizootics in facilities housing nonhuman primates. SVV infection of nonhuman primates is used as an experimental model to investigate varicella pathogenesis and to develop antiviral strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An indirect enzyme\u2010linked immunosorbent assay (ELISA) was developed to detect SVV antibodies in infected rhesus macaque monkeys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An ELISA determined SVV antibody titers following experimental infection. SVV IgG was detected by day 14 post\u2010infection and remained elevated for at least 84\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SVV ELISA is a safe and rapid approach to confirm SVV seropositivity and to determine SVV antibody titers in naturally and experimentally SVV\u2010infected monkeys. In addition to being a useful diagnostic assay to rapidly confirm acute disease or past SVV infection, the SVV ELISA is a valuable epidemiological tool to determine the incidence of SVV in non\u2010human primate facilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12552","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T05:59:26Z","timestamp":1636955966000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An enzyme\u2010linked immunosorbent assay (ELISA) to determine Simian Varicella Virus antibody titers in infected rhesus monkeys (<i>Macaca mulatta<\/i>)"],"prefix":"10.1111","volume":"51","author":[{"given":"Wayne L.","family":"Gray","sequence":"first","affiliation":[{"name":"Biology Department University of Mississippi Oxford Mississippi 38677 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