{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:52:48Z","timestamp":1782589968284,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute pancreatitis exhibits a rapid clinical progression which makes it difficult to observe in human; hence, an experimental animal model is needed. This preliminary study performed an induction of acute pancreatitis using glycodeoxycholic acid (GDOC) in an experimental macaque model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GDOC injections (initial dose of 11.20 mg\/kg) were administered in an escalating manner at specific time points. The injection was given along the bilio\u2010pancreatic duct, followed by measurement of vital signs, serum amylase\u2010lipase, TNF\u2010\u03b1, procalcitonin, oxidative stress parameters, and microscopic and macroscopic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated that acute pancreatitis occurred following induction with low\u2010dose GDOC. Serum amylase and lipase levels increased with subsequent GDOC injections. Blood pressure and heart rate were elevated, indicating abdominal pain. Changes in TNF\u2010\u03b1, procalcitonin, and oxidative stress values showed active inflammation. We observed histologic features of pancreatitis and as the dose increased, vasodilation of the splanchnic vasculatures was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Small dose GDOC injection in the bilio\u2010pancreatic duct may have a role to induce acute pancreatitis in <jats:italic>Macaca nemestrina<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12577","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T07:00:11Z","timestamp":1647759611000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of glycodeoxycholic acid to induce acute pancreatitis in <i>Macaca nemestrina<\/i>"],"prefix":"10.1111","volume":"51","author":[{"given":"Achmad","family":"Fauzi","sequence":"first","affiliation":[{"name":"Gastroenterology\u2010pancreatobiliarry and GI Endoscopy Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-0591","authenticated-orcid":false,"family":"Suhendro","sequence":"additional","affiliation":[{"name":"Tropical medicine Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellus","family":"Simadibrata","sequence":"additional","affiliation":[{"name":"Gastroenterology\u2010pancreatobiliarry and GI Endoscopy Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Azis","family":"Rani","sequence":"additional","affiliation":[{"name":"Gastroenterology\u2010pancreatobiliarry and GI Endoscopy Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dondin","family":"Sajuthi","sequence":"additional","affiliation":[{"name":"Primate Research Centre Institut Pertanian Bogor  Bogor Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Permanawati","sequence":"additional","affiliation":[{"name":"Primate Research Centre Institut Pertanian Bogor  Bogor Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosvitha","family":"Amanda","sequence":"additional","affiliation":[{"name":"Gastroenterology\u2010pancreatobiliarry and GI Endoscopy Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadang","family":"Makmun","sequence":"additional","affiliation":[{"name":"Gastroenterology\u2010pancreatobiliarry and GI Endoscopy Division Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i9.1006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6218798"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S135751"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2018-101102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40329.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2014.47.3.212"},{"issue":"9","key":"e_1_2_9_9_1","first-page":"801","article-title":"Why primate models matter","volume":"76","author":"Phillips KA","year":"2015","journal-title":"NIH Public Access"},{"key":"e_1_2_9_10_1","unstructured":"National Center for Biotechnology Information.Glycodeoxycholic acid. 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