{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:06:10Z","timestamp":1788825970013,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012692","name":"Yerkes National Primate Research Center, Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus type 2 has been linked to pancreatic islet amyloid deposition in humans and nonhuman primates. The authors hypothesized that diabetic primates would have significant differences in pathology than non\u2010diabetic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study used histopathology and immunohistochemistry to characterize and compare pancreatic islet amyloidosis in 58 diabetic and non\u2010diabetic rhesus macaque (RM) and sooty mangabeys (SM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pancreatic tissues from diabetic RM and SM showed higher histopathology scores for islet amyloid deposit distribution, severity, and calcification deposits compared to their respective non\u2010diabetic cohorts. Further, these tissues from RM and SM with amyloid deposits showed immunoreactivity to insulin, glucagon, islet amyloid polypeptide, serum amyloid P, and glucagon\u2010like peptide 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histopathology results showed that the defined amyloid characteristics are associated with clinical diabetes in both species. The immunohistochemistry results collectively suggest differences in pancreatic hormones and islet amyloid components among both species and diabetic status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12579","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T10:56:25Z","timestamp":1648724185000},"page":"155-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicopathologic characteristics of pancreatic islet amyloidosis in the rhesus macaque (<i>Macaca mulatta<\/i>) and sooty mangabey (<i>Cercocebus atys<\/i>)"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-3939","authenticated-orcid":false,"given":"Leeza","family":"Birdwell","sequence":"first","affiliation":[{"name":"Division of Animal Resources, Yerkes National Primate Research Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denyse","family":"Levesque","sequence":"additional","affiliation":[{"name":"Division of Animal Resources, Yerkes National Primate Research Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Machiah","sequence":"additional","affiliation":[{"name":"Division of Pathology, Yerkes National Primate Research Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-2717","authenticated-orcid":false,"given":"Sanjeev","family":"Gumber","sequence":"additional","affiliation":[{"name":"Division of Pathology, Yerkes National Primate Research Center Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-S002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815620628"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00402271"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/B978-0-12-381366-4.00014-6","volume-title":"Diabetes and Obesity Research Using Non\u2010Human Primates. 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