{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:03:11Z","timestamp":1787317391895,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Shigella spp<\/jats:italic>\n                      . are common enteric pathogens in captive non\u2010human primates. Treatment of symptomatic infections involves supportive care and antibiotic therapy, typically with an empirical choice of antibiotic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four clinically ill,\n                      <jats:italic>Shigella<\/jats:italic>\n                      PCR\u2010positive animals were randomly assigned to one of four treatment groups: single\u2010dose ceftiofur crystalline free acid (CCFA), single\u2010dose azithromycin gavage, a 5\u2010day tapering azithromycin dose, or 7\u2010day course of enrofloxacin. We hypothesized that all antimicrobial therapies would have similar efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Animals in all groups cleared\n                      <jats:italic>Shigella<\/jats:italic>\n                      , based on fecal PCR, and had resolution of clinical signs 2\u2009weeks after treatment. Eight out of nine clinically ill and PCR\u2010positive animals tested negative by fecal culture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Single\u2010dose CCFA, single\u2010dose azithromycin, and a 5\u2010day tapering course of azithromycin all performed as well as a 7\u2010day course of enrofloxacin in eliminating\n                      <jats:italic>Shigella<\/jats:italic>\n                      infection. Fecal PCR may be a better diagnostic than culture for\n                      <jats:italic>Shigella<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.12608","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:45:04Z","timestamp":1661996704000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A comparison of different antibiotic regimens for the treatment of naturally acquired shigellosis in rhesus and pigtailed macaques (\n                    <i>Macaca mulatta<\/i>\n                    and\n                    <i>nemestrina<\/i>\n                    )"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-1725","authenticated-orcid":false,"given":"Amanda Rae","family":"Maxwell","sequence":"first","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology Research Animal Resources, Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-5675","authenticated-orcid":false,"given":"Jessica Ann","family":"Herrod","sequence":"additional","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology Research Animal Resources, Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Kenneth","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology Research Animal Resources, Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"437","volume-title":"American College of Laboratory Animal Medicine, Nonhuman Primates in Biomedical Research","author":"James BL","year":"2012"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention.Shigella \u2013 Shigellosis | Shigella \u2013 Shigellosis | CDC. 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