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While viral infections are ubiquitous, viral transmissions to uninfected animals are incompletely defined. Management procedures of macaque colonies include cohorts that are Specific Pathogen Free (SPF). Greater understanding of viral transmission would augment SPF protocols. Moreover, vaccine\/challenge studies of human viruses would be enhanced by leveraging transmission of macaque viruses to recapitulate expected challenges of human vaccine trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study characterizes viral transmissions to uninfected animals following inadvertent introduction of RhCMV\/RRV\/SFV\u2010infected adults to a cohort of uninfected juveniles. Following co\u2010housing with virus\u2010positive adults, juveniles were serially evaluated for viral infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Horizontal viral transmission was rapid and absolute, reaching 100% penetrance between 19 and 78\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides insights into viral natural histories with implications for colony management and modeling vaccine\u2010mediated immune protection studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12621","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T06:00:37Z","timestamp":1663999237000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Horizontal transmission of endemic viruses among rhesus macaques (<i>Macaca mulatta<\/i>): Implications for human cytomegalovirus vaccine\/challenge 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