{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:32:06Z","timestamp":1747186326728,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Simian immunodeficiency virus (SIV) infection in rhesus macaques (<jats:italic>Macaca mulatta<\/jats:italic>) can lead to the development of SIV encephalitis (SIVE), which is closely related to human immunodeficiency virus (HIV)\u2010induced dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was done by analyzing SIV and SIVE encephalitis in infected <jats:italic>M. mulatta<\/jats:italic> hippocampus samples from two microarray data sets, identifying two groups of common differentially expressed genes and predicting associated protein interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that eight genes\u2014<jats:italic>MX1<\/jats:italic>, <jats:italic>B2M<\/jats:italic>, <jats:italic>IFIT1<\/jats:italic>, <jats:italic>TYMP<\/jats:italic>, <jats:italic>STAT1<\/jats:italic>, <jats:italic>IFI44<\/jats:italic>, <jats:italic>ISG15<\/jats:italic>, and <jats:italic>IFI27<\/jats:italic>\u2014affected the negative regulation of biological processes, hepatitis C and Epstein\u2013Barr viral infection, and the toll\u2010like receptor signaling pathway, which mediate the development of encephalitis after SIV infection. In particular, <jats:italic>STAT1<\/jats:italic> played a central role in the process by regulating biopathological changes during the development of SIVE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide a new theoretical basis for the treatment of encephalopathy after HIV infection by targeting <jats:italic>STAT1<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12656","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:17:00Z","timestamp":1686125820000},"page":"259-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulatory pathway underpinning the development of encephalitis after simian immunodeficiency virus infection in rhesus macaques (<i>Macaca 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