{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:37:47Z","timestamp":1753879067999,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020473","name":"Badan Riset dan Inovasi Nasional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020473","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014538","name":"Lembaga Pengelola Dana Pendidikan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cervical cancer is an abnormal growth of cervical tissue epithelial cells due to persistent human papilloma virus (HPV) infection. Cynomolgus monkeys (<jats:italic>Macaca fascicularis<\/jats:italic>) can be naturally and spontaneously infected with <jats:italic>M. fascicularis<\/jats:italic> Papillomavirus Type 3 (MfPV3), a virus that is phylogenetically closely related to human oncogenic HPV (HPV\u201016 and HPV\u201034), and therefore a potentially beneficial for modeling HPV disease. This study aims to evaluate the expression of the integrin alpha 6 (<jats:italic>ITG\u03b16<\/jats:italic>) receptor in cynomolgus monkeys spontaneously infected with MfPV3, which this receptor also found in human infected with HPV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was done on archived Formalin\u2010fixed Paraffin\u2010Embedded (FFPE) samples of uterine and cervix tissue of cynomolgus monkeys. Immunohistochemistry was also performed to quantify the expression levels of <jats:italic>ITG\u03b16<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed 80% of the samples positive Cervical Intraepithelial Neoplasia (CIN) and increased expression of <jats:italic>ITG\u03b16<\/jats:italic> significantly in Positive\u2010MfPV3 group than negative\u2010MfPV3 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This indicated the potential of cynomolgus monkeys as a spontaneous oncogenesis model of PV infection type.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.12690","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T07:18:55Z","timestamp":1705130335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical characterization of integrin alfa 6 in uterus and cervix of the cynomolgus monkeys (<i>Macaca fascicularis<\/i>) with <scp>MfPV3<\/scp> infection"],"prefix":"10.1111","volume":"53","author":[{"given":"Dyah","family":"Setyawaty","sequence":"first","affiliation":[{"name":"Primate Research Center IPB University  Bogor Indonesia"},{"name":"Primatology Graduate Study Program IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silmi","family":"Mariya","sequence":"additional","affiliation":[{"name":"Primate Research Center IPB University  Bogor Indonesia"},{"name":"Primatology Graduate Study Program IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia A.","family":"Prabandari","sequence":"additional","affiliation":[{"name":"Primate Research Center IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte Rahbaek","family":"Boilessen","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Johannes","family":"Holst","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda Shalahudin","family":"Darusman","sequence":"additional","affiliation":[{"name":"Primate Research Center IPB University  Bogor Indonesia"},{"name":"Primatology Graduate Study Program IPB University  Bogor Indonesia"},{"name":"School of Veterinary Medicine and Biomedical Science IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22991.1"},{"issue":"19","key":"e_1_2_8_3_1","first-page":"241","article-title":"Human papillomavirus vaccines: WHO position 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