{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:31Z","timestamp":1753878451917,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Common marmosets (<jats:styled-content style=\"fixed-case\"><jats:italic>Callithrix jacchus<\/jats:italic><\/jats:styled-content>) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non\u2010painful direct stimulation), MAC\u2010noci, MAC\u2010extb, and MAC\u2010awake, respectively, were measured for isoflurane with the up\u2010and\u2010down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50\u2010noci, Cp50\u2010extb, and Cp50\u2010awake, respectively, were measured for propofol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MAC\u2010noci and MAC\u2010extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC\u2010awake was not determined owing to technical difficulties. Cp50\u2010noci, Cp50\u2010extb, and Cp50\u2010awake were 9.45, 7.21, and 3.54\u2009\u03bcg\/mL, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.70006","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:45:04Z","timestamp":1740033904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (<i>Callithrix jacchus<\/i>)"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-1538","authenticated-orcid":false,"given":"Kanako","family":"Muta","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"},{"name":"Division of Regenerative Medicine, Research Center for Medical Sciences The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Facilities, Research Center for Medical Sciences The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Miyabe\u2010Nishiwaki","sequence":"additional","affiliation":[{"name":"Center for Human Evolution Modeling Research, Center for the Evolutionary Origins of Human Behavior Kyoto University  Kyoto Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Sotomaru","sequence":"additional","affiliation":[{"name":"Natural Science Center for Basic Research and Development Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Nobukiyo","sequence":"additional","affiliation":[{"name":"Natural Science Center for Basic Research and Development Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine, Research Center for Medical Sciences The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka James","family":"Okano","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine, Research Center for Medical Sciences The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kamata","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Nagakubo","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.10.018"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Current Status of and Perspectives on the Application of Marmosets in Neurobiology","volume":"44","author":"Okano H.","year":"2020","journal-title":"Annual Review of Neuroscience"},{"key":"e_1_2_10_4_1","article-title":"Current Topics in Marmoset Anesthesia and Analgesia","volume":"61","author":"Goodroe A.","year":"2021","journal-title":"ILAR Journal"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac406"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12168"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1965.10480843"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196511000-00010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198703000-00006"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198105000-00008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/82.6.852"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199609000-00012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200110000-00029"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.1.81"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199410000-00008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539\u2010199510000\u201000014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199804000-00036"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2016.03.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0468"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2010.00564.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12905"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0003-2409.2001.02446.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199705000-00008"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010199305000\u201000009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1994.tb00234.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198803000-00020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2011.00615.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2995.2004.00165.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2995.2002.00107.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael116"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200109000-00028"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197401000-00012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679\u20109216.132347"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1258\/la.2011.011092"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199376060-00021"},{"key":"e_1_2_10_36_1","first-page":"452","article-title":"Minimum Alveolar Concentration and Cardiopulmonary Effects of Isoflurane in Ring\u2010Tailed Lemurs (Lemur catta)","volume":"56","author":"Chinnadurai S. K.","year":"2017","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12266"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199708000-00007"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.6.703"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2017.01.021"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.06.009"}],"container-title":["Journal of Medical Primatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jmp.70006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T05:32:40Z","timestamp":1748669560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jmp.70006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jmp.70006"],"URL":"https:\/\/doi.org\/10.1111\/jmp.70006","archive":["Portico"],"relation":{},"ISSN":["0047-2565","1600-0684"],"issn-type":[{"type":"print","value":"0047-2565"},{"type":"electronic","value":"1600-0684"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"2024-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70006"}}