{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:38:00Z","timestamp":1753879080788,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020473","name":"Badan Riset dan Inovasi Nasional","doi-asserted-by":"publisher","award":["the 2024 Rumah Program Grant 6\/III.9\/HK\/2024"],"award-info":[{"award-number":["the 2024 Rumah Program Grant 6\/III.9\/HK\/2024"]}],"id":[{"id":"10.13039\/100020473","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anemia, characterized by low hemoglobin, is a key malaria indicator. Malaria in non\u2010human primates (NHPs) is often asymptomatic, requiring laboratory tests and microscopy for diagnosis. Hematological profiles are crucial for understanding NHP clinical conditions and supporting ex\u00a0vivo <jats:italic>Plasmodium<\/jats:italic> culture for antimalarial testing. This study examines hematological changes in <jats:styled-content style=\"fixed-case\"><jats:italic>Macaca fascicularis<\/jats:italic><\/jats:styled-content> naturally infected with <jats:italic>Plasmodium inui<\/jats:italic> and provides hematocrit guidelines for ex\u00a0vivo culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten <jats:styled-content style=\"fixed-case\"><jats:italic>M. fascicularis<\/jats:italic><\/jats:styled-content> were diagnosed with <jats:italic>Plasmodium inui<\/jats:italic> in 2023 and subsequently re\u2010screened in this study through microscopic and molecular analyses. Two monkeys (M4, M10) with the highest parasitemia and one negative control (M6) were analyzed. Hematological, albumin, and glucose levels were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>M4 and M10 showed 34.5% and 30.2% hematocrit values, with hemoglobin levels of 10.5 and 8.6\u2009g\/dL. M10 exhibited anemia and thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>M10 showed hematological signs of malaria, while all macaques exhibited microcytic hypochromic anemia. High hematocrit levels are recommended for ex\u00a0vivo culture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jmp.70011","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:51:39Z","timestamp":1741773099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hematological Profile of Naturally Infected Long\u2010Tailed Macaques (<i>Macaca fascicularis<\/i>) With <i>Plasmodium Inui<\/i> in Ex Situ Captivity Prior to Ex\u00a0Vivo Cultivation"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-7927","authenticated-orcid":false,"given":"Risqa","family":"Novita","sequence":"first","affiliation":[{"name":"Primatology Study Program Graduate School of IPB University  Bogor Indonesia"},{"name":"Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research, and Innovation Agency (BRIN)  Cibinong Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agik","family":"Suprayogi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, School of Veterinary Medicine, and Biomedical Sciences IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andria","family":"Agusta","sequence":"additional","affiliation":[{"name":"Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research, and Innovation Agency (BRIN)  Cibinong Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arifin Budiman","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Division of Parasitology and Medical Entomology, School of Veterinary Medicine and Biomedical Sciences IPB University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda Shalahudin","family":"Darusman","sequence":"additional","affiliation":[{"name":"Primatology Study Program Graduate School of IPB University  Bogor Indonesia"},{"name":"Primate Research Center Bogor Agricultural University  Bogor Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"volume-title":"World Malaria Report 2023","year":"2023","author":"World Health Organization","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(23)00298\u20100"},{"volume-title":"Field Guide to the Primates of Indonesia","year":"2022","author":"Jaya S.","key":"e_1_2_9_4_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010022\u201004129\u20102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2708.204502"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10393\u2010022\u201001586\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taad135"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/tp.tp_79_22"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01249-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.876282"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"90","article-title":"Current Medicines for Malaria Including Resistance Issues","volume":"11","author":"Nureye D.","year":"2020","journal-title":"Journal of Pharmacology and Pharmacotherapeutics"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010022\u201004261\u2010z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00772-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2021.102432"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5060665"},{"issue":"119","key":"e_1_2_9_17_1","first-page":"1","article-title":"In Vitro and In\u00a0Vivo Studies on Anti\u2010Malarial Activity of Commiphora Africana and Dichrostachys cinerea Used by the Maasai in Arusha Region, Tanzania","volume":"18","author":"Kweyamba P. 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