{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:35:47Z","timestamp":1765514147157,"version":"3.48.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003768","name":"Universit\u00e9 de Strasbourg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003768","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular and hemodynamic status can both be modified by cardiovascular risk factors which themselves depend on housing conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cynomolgus macaques maintained in large enclosures allowing them to perform physical exercise and social interactions were evaluated for cardiovascular and metabolic parameters in three age groups (2\u20134, 5\u201310, and 10\u201315).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Liver and kidney functions were stable but an important variability of the blood neutrophil count was noticed. In males, an increase in alkaline phosphatase was noted in young animals while lipid parameters were altered over time with increases in triglycerides and cholesterol. Some diastolic disorders were observed in older males. No electrocardiographic abnormalities were observed. Finally, we observed usual physiological changes due to gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Housing conditions closer to those in the wild provide an improved health status over non\u2010human primates that are housed in more crowded housing conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70041","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T04:30:28Z","timestamp":1763440228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Cross\u2010Sectional Evaluation of Cardiovascular and Metabolic Functions During Aging and Pregnancy in the Cynomolgus Monkey"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0064-3722","authenticated-orcid":false,"given":"Lyne","family":"Fellmann","sequence":"first","affiliation":[{"name":"Silabe\u2010Universit\u00e9 de Strasbourg Fort Foch  Niederhausbergen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6784-5147","authenticated-orcid":false,"given":"Pierrick","family":"Regnard","sequence":"additional","affiliation":[{"name":"Silabe\u2010Universit\u00e9 de Strasbourg Fort Foch  Niederhausbergen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-6103","authenticated-orcid":false,"given":"Sylvia","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire, UR7296 Universit\u00e9 et Centre Hospitalier et Universitaire  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-0267","authenticated-orcid":false,"given":"Guillaume","family":"Becker","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire, UR7296 Universit\u00e9 et Centre Hospitalier et Universitaire  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-2109","authenticated-orcid":false,"given":"Fan\u00e9lie","family":"Wanert","sequence":"additional","affiliation":[{"name":"Silabe\u2010Universit\u00e9 de Strasbourg Fort Foch  Niederhausbergen France"},{"name":"Institute of Image\u2010Guided Surgery  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-4986","authenticated-orcid":false,"given":"Laurent","family":"Monassier","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologie et Toxicologie NeuroCardiovasculaire, UR7296 Universit\u00e9 et Centre Hospitalier et Universitaire  Strasbourg 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of Age and Sex on the Hematology and Blood Chemistry of Tibetan Macaques (Macaca thibetana)","volume":"53","author":"Wu D.","year":"2014","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064892"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.11.1081"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072241"}],"container-title":["Journal of Medical 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