{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:35:49Z","timestamp":1765514149012,"version":"3.48.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202001BC070001and 202102AA100053"],"award-info":[{"award-number":["202001BC070001and 202102AA100053"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007301","name":"Kunming University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tongue squamous cell carcinoma (TSCC) is a typical and prevalent neoplasm in non\u2010human primates (NHPs). However, comprehensive pathological and immunohistochemical analyses of TSCC in rhesus monkeys have been infrequently documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three rhesus monkeys with TSCC were sourced from the same breeding facility. Laboratory tests, gross observation of the lesion tissue, and human papillomavirus content testing using real\u2010time fluorescence PCR method of the animals were carried out. The animals underwent necropsy for examination of tissues and organs, followed by histopathological and immunohistochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The clinical manifestations observed across all animals included salivation, swelling, sclerosis, and ulceration of the tongue. All three rhesus monkeys were euthanized due to deteriorating health conditions. No abnormalities were noted in other organs during post\u2010mortem examination except for their tongues. Histopathological examination revealed an invasive tumor characterized by nests of polygonal cells within the stroma, accompanied by significant desmoplastic reactions and occasional cancerous beads. All cases demonstrated positive immunolabeling for p63, CK5\/6, p40, CK19, CK7, and CK20 via immunohistochemistry (IHC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5\/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70045","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:15:31Z","timestamp":1764130531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Squamous Cell Carcinoma of the Tongue in Captive Rhesus Monkeys (\n                    <scp>\n                      <i>Macaca mulatta<\/i>\n                    <\/scp>\n                    )"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8264-8529","authenticated-orcid":false,"given":"Heling","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengbo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kunming Biomed International Ltd.  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6763-3168","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming China"},{"name":"Yunnan Key Laboratory of Primate Biomedical Research  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-19-2076"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00233-07"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519897187"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00098.2022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0684.2009.00338.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.49.225"},{"key":"e_1_2_10_8_1","first-page":"469","article-title":"Squamous Cell Carcinoma With Metastasis in a Rhesus Monkey (\n                     Macaca mulatta\n                  )","volume":"33","author":"Hubbard G. 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