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We sought to compare two techniques for evaluation of placental perfusion in a translational nonhuman primate model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured placental microvascular perfusion in six pregnant African green monkeys (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">Chlorocebus aethiops<\/jats:styled-content>\n                        sabaeus\n                      <\/jats:italic>\n                      ) using both Laser Doppler Flowmetry (LDF) and contrast\u2010enhanced ultrasound (CEUS) in 2\u20134 discrete placental locations per animal at early\u2010 (EG), mid\u2010 (MG), and\/or late\u2010gestation (LG). We assessed correlation between matched LDF and CEUS, with the hypothesis that we would observe concordance between these two measures of relative perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using 35 total paired measurements (13 EG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094; 12 MG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094; 10 LG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095), we found no correlation between LDF microvascular perfusion and CEUS microvascular flux rate (Pearson\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.2026,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0411,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2431).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDF and CEUS produce discordant results with respect to placental perfusion. LDF is ill\u2010suited to a heterogeneous organ such as the placenta.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70059","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:44:33Z","timestamp":1769665473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Laser Doppler Flowmetry With Contrast\u2010Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey (\n                    <i>Chlorocebus aethiops sabaeus<\/i>\n                    )"],"prefix":"10.1111","volume":"55","author":[{"given":"Yarines","family":"Gonzalez\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Animal Resources Program Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel 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