{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:09:04Z","timestamp":1783699744769,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","award":["22042\/IT3.D10\/PT.01.03\/P\/B\/2024"],"award-info":[{"award-number":["22042\/IT3.D10\/PT.01.03\/P\/B\/2024"]}],"id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Primatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colon cancer death toll due to metastasis is expected to rise. Extracellular vesicles are signalling molecules which can regulate communication between cells and either inhibit or promote cancer metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Extracellular vesicles from adipose mesenchymal stem cells of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Macaca fascicularis<\/jats:italic>\n                      <\/jats:styled-content>\n                      were obtained from previous research. Various concentrations of extracellular vesicles (5\u2009\u03bcg\/mL, 10\u2009\u03bcg\/mL, and 20\u2009\u03bcg\/mL) were applied to colon cancer cell line WiDr in a transwell invasion assay. CXCR3 gene expression analysis was done using RT\u2010qPCR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Application of extracellular vesicles successfully inhibited colon cancer invasion with decrease of number of invasive cells with increase in concentration. There was no statistical difference between cells treated with 10\u2009\u03bcg\/mL and 20\u2009\u03bcg\/mL of extracellular vesicles. Colon cancer cells treated with extracellular vesicles show upregulation of CXCR3A and CXCR3B gene expression compared to negative control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Extracellular vesicles inhibit colon cancer cell invasion through upregulation of CXCR3B expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jmp.70080","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:29:36Z","timestamp":1779074976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anticancer Activity of Extracellular Vesicles Derived From Adipose Mesenchymal Stem Cells of\n                    <scp>\n                      <i>Macaca fascicularis<\/i>\n                    <\/scp>\n                    on\n                    <scp>WiDr<\/scp>\n                    Colon Cancer Cells"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9874-5409","authenticated-orcid":false,"given":"Fadia Walid","family":"Al\u2010Ozeir","sequence":"first","affiliation":[{"name":"Biotechnology Graduate School IPB University  Bogor Regency West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni Luh Putu Ika","family":"Mayasari","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences IPB University  Bogor Regency West Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-1276","authenticated-orcid":false,"given":"Silmi","family":"Mariya","sequence":"additional","affiliation":[{"name":"Primate Research Centre IPB University  Bogor City West Java 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